Secondary metabolites of natural origin exhibit numerous pharmacological activities like anti-inflammatory and anti-oxidant effects. Lipid peroxidation is observed to be prevented by terminating free radical chains and chelating redox active metal ions. These properties of the secondary products can also aid in preventing carcinoma. Many traditional and emerging plants are blessed with plenty of unexplored phytometabolites, which contain the probability to carry huge anti-neoplastic potential. Acetogenins are anticancer compounds that kill tumor cells through a variety and series of developmental methods. They are very powerful apoptosis inducers and can regulate the exclusion of chemotherapy medicines from cancer cells. Chalcone is a pharmacologically active molecule that can be found in both natural and manufactured products. Marine species, which are also examples of naturally derived drug sources such as algae, sponges, tunicates, and bryozoans have emerged as important components of choice for the separation of novel anticancer drugs obtained from marine sources. Bacteria of marine origin are the source of new drug discoveries and therapeutic targets, which are being explored to unprecedented heights and they have proven to be sources of various medicinal agents such as antibiotics etc. Numerous secondary metabolites have been isolated from marine fungi, that were active biologically and unique structural and also therapeutically beneficial. So far, almost 1000 secondary metabolites have been found, the majority of which are exclusive to lichens. This mini-review aims for the discussion of different aspects related to the natural derivatives obtained from various sources, which play a pivotal role as anti-neoplastic agents.
Sesquiterpenes are important in human health because they can treat viral infection, cardiovascular disease, and cancer. Sesquiterpenes have also been shown to increase the sensitivity of tumor cells to conventional pharmacological therapies, in addition to their antiviral effects. The present review article was drafted with an intention to gather information regarding sesquiterpenes and its medicinal importance. The role of sesquiterpenes in the endogenous production of sesquiterpenes by plants and fungi, as well as the mechanisms by which they are effective against viral infection, are discussed in this review. Different online libraries such as PUBMED, Sciencedirect, MEDLINE were assessed to gather information, additionally, books, magzagines, journals, and scientific newspapaers were also studied to make this article more informative. This review examines novel synthesis mechanisms, their cyclization, purification techniques, and the diverse ecological roles sesquiterpenes play in the plant producer, which varies according to the plant and the chemical under consideration. In this article, we have discussed the consequences of sesquiterpenes and their properties for future crop productivity. We have addressed the many forms of sesquiterpenes that have been shown to have antiviral activity in various diseases. The consequences of sesquiterpenes and their properties are very useful for future crop productivity. We have addressed the many forms of sesquiterpenes that have been shown to have antiviral activity in the treatment of various diseases. Practical applications Novel synthesis mechanisms, their cyclization, purification techniques, and the diverse ecological roles of sesquiterpenes will be very helfpul in drug development process. Sesquiterpene lactones are shown in this review to have qualities that warrant further scientific investigation in order to stimulate preclinical and clinical trials leading to the creation of novel medications. For antiviral drug development, the sesquiterpenes are a good prospective lead molecule because they can suppress viral replication by disrupting vRNA production and viral protein production.
Background: Nature has bestowed mother Earth with an array of herbals utilized as therapeutics for various human ailments since the origin of life. Bryonia laciniosa (family: Cucurbitaceae) is one such herb which finds its mention in various traditional systems of medicine and has attracted the current researchers due to its significant therapeutic value. Objective: The current article aims to present a literature metasynthesis on Bryonia laciniosa. Method: The authors performed the scholarly searches for peer-reviewed findings on Bryonia laciniosa and incorporated all the data related to the phytochemical and therapeutic profile of the drug. Results: This compilation comprises of Phytochemical and Pharmacological profile of Bryonia laciniosa elaborating its traditional significance and recent researches related to its biological activities. The plant exhibits its potential as antimicrobial, anti-inflammatory, analgesic, antipyretic, anticonvulsant, anti-asthamatic, anticancer, antioxidant, antidiabetic and aphrodiasiac agent. Also displays its benefits in wound healing and ulcerative colitis. Conclusion: The presence of flavonoids, saponins, terpenoids, anthocyanins, coumarins, alkaloids, polyphenols, tannins and emodins in this plant is responsible for its various pharmacological activities. The retrospective study provides direction for existing research as well as future studies to support the domain of pharmaceutical and medical sciences.
Background: Fungal infections have become a worldwide problem due to their involvement in numerous diseases. The risk factors for fungal infections are multiple surgeries, transplant therapies, frequent administration of antibiotics, cancer treatments, and prosthetic devices. The problem of resistance in fungi against drug therapies is widespread, becoming a severe health-related problem. Objective: The study's objective was to identify molecular targets that may open new paths for fungal treatment. Methods: Several research and review articles were studied to gather information regarding the novel mechanism of antifungal drugs. However, identifying novel targets is challenging due to the similarities between host and fungal cells. Although, the plasma membrane and cell wall of fungus offer various drug targets that may target to fight against microbial infections. Unfortunately, biofilm formation and over-expression of protein are a few mechanisms through which fungi develop resistance. Results: Despite these problems, several approaches have been working to prevent and treat fungal infections. Modifying the chemical structure of antifungal drugs may also improve their activity and pharmacokinetics. In this review article, we have discussed the molecular targets and novel techniques to be used for the development of antifungal drugs. In addition, different strategies to overcome resistance in fungi have also been described. Conclusion: This article may be helpful for the researchers working on the discovery and development of new antifungal works for resistance to fungal diseases.
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