Besides the overriding influence of anti-HLA antibodies on the overall graft survival, immune response to non-HLA antigens has become a subject of substantial interest in recent years. The much-needed impetus towards understanding the relevance of non-HLA antibodies has come from multicentric analysis involving a large cohort of renal allograft recipients and published under the aegis of the Collaborative Transplant Study (CTS). 1 Subsequently, several investigators have highlighted an important role of non-HLA antibodies not only in kidney transplants, but also in those involving other organs such as heart and lung. 2-7 Major histocompatibility complex class I chain-related molecule A (MICA), the most notable
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