Background: Acute falciparum Malaria infected patients show wide ranges of metabolic derangement including changes in serum lipid profiles. The exact mechanisms of this derangement in serum lipid profiles are still poorly understood. Objective was to study the lipid profiles among acute plasmodium falciparum infected patients.Methods: It was a Prospective observational comparative study. A total of 100 patients were consecutively taken in the study. Fifty Non- malaria febrile cases and 50 healthy volunteers were taken as control group. Baseline lipid profiles were estimated in all cases at the time of admission and at the end of one week. Data were collected and analyzed.Results: There were 100 diagnosed cases of falciparum malaria and 50 non malarial febrile and 50 healthy volunteers taken as control group. Complications was present in 50 and 50 were uncomplicated. Serum total cholesterol, HDL and LDL levels were significantly low in falciparum malaria patients, and serum TG and VLDL levels were higher than control. There were no significant changes in mean serum lipids profiles in survived and deaths cases.Conclusions: The derangement in lipid profiles in falciparum malaria was characteristic and specific for the disease. Characteristic changes were lower HDL, LDL and total cholesterol levels and higher TG and VLDL levels in comparison to control groups. Changes are more pronounced in complicated falciparum Malaria and persisting till the end of the week. These findings may be of diagnostic and prognostic value.
Chiral stirred optical and magnetic properties, through the doping of assembled ultrasmall metal clusters (AMCs), are promising discernment to rivet the molecule-like quantum devices. Here, the single manganese (Mn) atom doping and assembly of the gold cluster (Au 8 ), leading to the chirality driven magnetism, has been achieved through a ligandmediated growth. The X-ray absorption near edge structure and electron paramagnetic resonance studies corroborate the tetrahedral coordinated local structure of Mn dopant in the Au host. The optical and vibrational circular dichroic analysis affirms the modulation of chirality (negative to positive) in the presence of the Mn. A distinct ferromagnetic hysteresis loop at 300 K shows Mn ridden chiral sensitive ferromagnetism in contrary to the ligand influenced superparamagnetic undoped AMCs. The spin-polarized density functional theory level of calculations reveal the partial overlapping of spin-up and -down density of states in the doped AMCs, attributing to the ferromagnetic nature as like a molecular magnet suitable for the opto-spintronics application.
Bovine serum albumin (BSA)-protected gold clusters (atomicity ∼ 20), prepared using a wet chemical route, show strong dipolar radiative transition with a gap energy of 1.93 eV due to the high oscillator strength, as confirmed by the emission studies. Self-arrangement of the clusters with fixed atomicity yields a low dispersive dielectric and electric self-polarization nature. The electrical hysteresis loop measurements returned a remanent polarization of 0.05 μC cm, which can be correlated with the dipolar orientation (activation energy ∼ 45.32 meV), originating from the structure-dependent deformation of the charge density.
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