Lipid profiles among Plasmodium falciparum infected, non malarial febrile patients and volunteers

Kullu, Bipin Kishore; Majhi, Chakradhar; Pradhan, B. B.; Swain, Deepak K.

doi:10.18203/2349-3933.ijam20181661

Cited by 5 publications

(5 citation statements)

References 6 publications

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“…Except for HDL, these study results are in line with a study reported from Nigeria where TG(0.170), TC (0.18), HDL (2.36), and LDL (-2.7) mg/dl were reported; in Gabon where TC(-12.98), HDL-C (-9.55); LDL(-9.96),and TG levels (0.9) were reported (22,41) in mg/dl of mean difference of pre-and post-treatment, respectively. The mean difference in our findings is inconsistent with the mean difference of other study reports from Nigeria where HDL(1.28), LDL (5.51),TG(4.41),and TC(-6.49) (42), and in India where TC(-12.34),HDL(-1.44), LDL (-3.19) and TG (11.42), respectively (43).The possible explanation for this variation might be due to the physiological, environmental, host immunity, and nutritional status differences.…”

Section: Serum Liver Enzymes and Lipid Profiles In Different Level Of Parasitaemia Among Malaria-infected Patients Before Anti-malaria Trcontrasting

confidence: 99%

Liver enzymes and lipid profile of malaria patients before and after antimalarial drug treatment at Dembia Primary Hospital and Teda Health Center, Northwest, Ethiopia

Megabiaw

Eshetu

Kassahun

et al. 2021

Preprint

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Backgroundinfection with malaria in humans involves liver cell destruction, which alters the levels of liver enzymes and lipid profiles. Although a number of studies have been conducted to address the impact of malaria on liver enzymes and lipid profiles, their findings lack consistency and no studies were conducted after antimalarial drug treatment in the Ethiopian context. This study, therefore, is intended to fill this gap. MethodsAn observational cohort study was conducted at Dembia Primary Hospital and Teda Health Center, from June to August 2020. A total of 88 study participants were recruited using random sampling techniques. Socio-demographic data, capillary and venous blood samples were collected from confirmed Plasmodium -infected individuals. Assessment of liver enzymes and lipid profiles was done using Beckman Coulter DC-700 clinical chemistry analyzer. Data were entered using Epi-data and exported to SPSS version 20 software for analysis. One way ANova, independent t-test, and paired t-test were used to compare the mean liver enzymes and lipid profile. A p -value<0.05 was considered statistically significant. RESULTSBefore anti-malaria treatment, among 88 malaria-infected study participants, abnormally elevated AST was observed in 87.5% of them. Similarly, elevated ALT, ALP, and TG were observed among 12.5%, 43.2%, and 17.2% of the study subjects, respectively. A lower level of HDL was observed among 87.5% of the study participants, while LDL and TC levels were within the normal range. After anti-malaria treatment,100% of AST, ALT, HDL, and LDL, and 92% of ALP, 94.3% of TC, and 86.4% of TG results were in the normal range. The mean level of AST (39.70±3.55and 55.35±9.6) and ALT (22.11±11.75, and23.24±16.05) results were increased, whereas HDL (28.88±11.63and22.73±14.26) level decreased from low to higher density parasitaemia. The mean level of AST at posttreatment (33.90±15.15) was significantly lower compared to the pretreatment (47.60±9.65). The mean levels of ALT had not altered during pretreatment(23.53±16.28)and posttreatment (23.49±11.10).Moreover, the mean of HDL, LDL, and TC at posttreatment were found to be increased when compared with pretreatment, though it is statistically insignificant ( P >0.05). CONCLUSIONMalaria parasites could be responsible for increased liver enzymes and certain lipids while decreasing some lipid profiles compared with the normal range. After anti-malaria treatment, these parameters were reversed to normal from 86.4% to 100%. When the mean values are compared, a significant change was observed in AST level while ALT level remains the same. Hence, prompt treatment is important to improve liver enzymes and lipid profile impairment during malaria infection.

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Section: Serum Liver Enzymes and Lipid Profiles In Different Level Of Parasitaemia Among Malaria-infected Patients Before Anti-malaria Trcontrasting

confidence: 99%

Liver enzymes and lipid profile of malaria patients before and after antimalarial drug treatment at Dembia Primary Hospital and Teda Health Center, Northwest, Ethiopia

Megabiaw

Eshetu

Kassahun

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…26,46 The mean difference in our findings is inconsistent with the mean difference of other study reports from Nigeria where HDL (1.28), LDL (5.51), TG (4.41), and TC (−6.49), 47 and from India where TC (−12.34), HDL (−1.44), LDL (−3.19) and TG (11.42), is reported respectively. 48 The possible explanation for this variation might be due to the physiological, environmental, host immunity, and nutritional status differences.…”

Section: Discussionmentioning

confidence: 99%

Liver Enzymes and Lipid Profile of Malaria Patients Before and After Antimalarial Drug Treatment at Dembia Primary Hospital and Teda Health Center, Northwest, Ethiopia

Megabiaw¹,

Eshetu²,

Kassahun³

et al. 2022

RRTM

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Background: Infection with malaria in humans involves liver cell destruction, which alters the levels of liver enzymes and lipid profiles. A number of studies have been conducted to address the impact of malaria on liver enzymes and lipid profiles but no studies were addressed after antimalarial treatment in Ethiopia. This study is intended to fill this gap. Methods: An observational cohort study was conducted at Dembia Primary Hospital and Teda Health Center, from June to August 2020. Eighty eight malaria infected study participants were recruited using random sampling techniques. Sociodemographic data, capillary and venous blood samples were collected. Assessment of liver enzymes and lipid profiles was done using Beckman Coulter DC-700 clinical chemistry analyzer. Data were entered using Epi-data and exported to SPSS version 20 for analysis. One way ANOVA, independent t-test, and paired t-test were used to compare the mean liver enzymes and lipid profile. p-value<0.05 was considered statistically significant. Results: Before anti-malaria treatment, among 88 study participants, elevated AST (87.5%), ALT (12.5%), ALP (43.2%), and TG (17.2%) and lower HDL (87.5%) and normal LDL and TC were observed. After treatment, 100% AST, ALT, HDL, and LDL and 92% ALP, 94.3% TC, and 86.4% TG levels were in the normal range. The mean level of AST and ALT increased while HDL decreased from low to higher density parasitaemia. Mean level of AST was significantly lower while ALT did not alter. HDL, LDL, and TC level were increased but statistically were insignificant (P>0.05). Conclusion: Malaria could be responsible for increased liver enzymes and certain lipids while decreasing some lipid profiles. After anti-malaria treatment, these parameters were reversed to normal from 86.4% to 100%. Hence, prompt treatment is important to improve liver enzymes and lipid profile impairment during malaria infection.

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“…For instance, P. vivax -infected patients were observed to have lower TC, LDL, and HDL levels while having higher TAG levels when compared to normal/apparently healthy individuals ( Mesquita et al, 2016 ). Falciparum malaria has also been associated with decreased levels of HDL, LDL, and total cholesterol as well as increased or unaltered levels of TAGs and very low-density lipoproteins (VLDL) ( Kullu et al, 2018 ). Of note, following antimalarial medication therapy, these changes in lipid levels normalized along with a significant decrease in parasitemia and the eradication of clinical symptoms of malaria.…”

Section: Resultsmentioning

confidence: 99%

Malaria: biochemical, physiological, diagnostic, and therapeutic updates

El Saftawy,

Farag,

Gebreil

et al. 2024

PeerJ

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Background Malaria has been appraised as a significant vector-borne parasitic disease with grave morbidity and high-rate mortality. Several challenges have been confronting the efficient diagnosis and treatment of malaria. Method Google Scholar, PubMed, Web of Science, and the Egyptian Knowledge Bank (EKB) were all used to gather articles. Results Diverse biochemical and physiological indices can mirror complicated malaria e.g., hypoglycemia, dyslipidemia, elevated renal and hepatic functions in addition to the lower antioxidant capacity that does not only destroy the parasite but also induces endothelial damage. Multiple trials have been conducted to improve recent points of care in malaria involving biosensors, lap on-chip, and microdevices technology. Regarding recent therapeutic trials, chemical falcipain inhibitors and plant extracts with anti-plasmodial activities are presented. Moreover, antimalaria nano-medicine and the emergence of nanocarrier (either active or passive) in drug transportation are promising. The combination therapeutic trials e.g., amodiaquine + artemether + lumefantrine are presented to safely counterbalance the emerging drug resistance in addition to the Tafenoquine as a new anti-relapse therapy. Conclusion Recognizing the pathophysiology indices potentiate diagnosis of malaria. The new points of care can smartly manipulate the biochemical and hematological alterations for a more sensitive and specific diagnosis of malaria. Nano-medicine appeared promising. Chemical and plant extracts remain points of research.

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Lipid profiles among Plasmodium falciparum infected, non malarial febrile patients and volunteers

Cited by 5 publications

References 6 publications

Liver enzymes and lipid profile of malaria patients before and after antimalarial drug treatment at Dembia Primary Hospital and Teda Health Center, Northwest, Ethiopia

Liver enzymes and lipid profile of malaria patients before and after antimalarial drug treatment at Dembia Primary Hospital and Teda Health Center, Northwest, Ethiopia

Liver Enzymes and Lipid Profile of Malaria Patients Before and After Antimalarial Drug Treatment at Dembia Primary Hospital and Teda Health Center, Northwest, Ethiopia

Malaria: biochemical, physiological, diagnostic, and therapeutic updates

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