Aim: The aim of this study was to compare push-out bond strength of root canal spaces filled with AH-Plus and BioRoot RCS after using different irrigants. Materials and Methods: Eighty single-rooted teeth were decoronated and endodontically treated by crown-down technique using ProTaper Universal rotary files progressively till F4 (40/0.06). Samples were divided into two groups according to the sealer ( n = 40): Group A = BioRoot RCS, Group B = AH Plus, further subdivided into four subgroups according to irrigation protocol ( n = 10): Group 1A, 1B – 0.9% saline, Group 2A, 2B – 5.25% NaOCl + 17% EDTA, Group 3A, 3B– 17% EDTA +2% chlorhexidine, and Group 4A, 4B – 17% EDTA + 3% green tea extract. Samples were obturated with sealers and prepared for push-out test with root slices of 2 mm thickness using universal testing machine. Data were statistically analyzed using two-way ANOVA, Bonferroni's post hoc analysis, and independent Student's t -test. Results: BioRoot RCS exhibited significantly higher push-out bond strength ( n < 0.001). The interaction between irrigants and sealer showed higher bond strength for BioRoot RCS when 17% EDTA+ green tea was used. Conclusion: Within the limitation of the study, it was concluded that bond strength of a sealer was influenced by the irrigants used.
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