Combining anti-inflammatory agent derived from plant essential oil like cinnamaldehyde to bioabsorbable and osteoconductive material for bone substitute is a challenge in biomedical technology. In this study, cinnamaldehyde as a good anti-inflammatory agent with an aromatic α, β-unsaturated aldehyde derived from cinnamon was loaded to a composite of Plaster of Paris (POP) and hydrogel calcium carbonate (CaCO3) for bone substitute. However, it must be considered that blood-biomaterial interactions begin to occur after surgical implantation with blood protein adsorption to the biomaterial surface prior to interacting with host cell. Therefore, before the device is ready for implantation, the influence of cinnamaldehyde to the property of the composite, especially its surface characteristics, needs to be investigated. The aim of this research was to investigate the effect of cinnamaldehyde on the surface topography, contact angle, and surface roughness of POP-hydrogel CaCO3 scaffold. The results indicated that cinnamaldehyde increased the contact angle, increased surface roughness of the POP-hydrogel, and seem to be homogenous in all surfaces.
CaCO3 hydrogel incorporation into Plaster of Paris (POP) formulations decreased the resorption rate of the POP after implantation in the body. Although an inflammatory process is required as part of wound healing, the accumulation and activation of inflammatory cells in the POP–hydrogel CaCO3 implant area needs to be controlled. Therefore, cinnamaldehyde, as an anti-inflammatory agent with a unique α, β-unsaturated aldehyde, was incorporated into the CaCO3 hydrogel. During the incorporation, both the lipophilic and hydrophilic sides of the cinnamaldehyde molecule can influence the physical and mechanical properties of the CaCO3 hydrogel, in which mechanical properties of a tissue engineering scaffold are important to fine tune cellular activity during implantation. On the other hand, as a 3-dimensional polymeric structure, crosslinking is needed for the CaCO3 hydrogel to stabilize and increase its molecular weight for better mechanical strength, and more resistance to heat, wear, and solvent attack. For that purpose, dehydrothermal treatment (DHT) was applied to the crosslink hydrogel system as a favorable crosslinking method to avoid the use of a chemical agent. In this study, 3 groups of hydrogels of CaCO3, namely DHT crosslinked, loaded with cinnamaldehyde, and loaded with cinnamaldehyde followed by DHT crosslinking were developed before being combined with POP in 50 wt%. To evaluate the effect of DHT to the final POP-cinnamaldehyde-loaded CaCO3 hydrogel properties and biocompatibility, scanning electron microscopy, contact angle, surface roughness, hardness, diametral tensile strength, and in vivo biocompatibility studies were conducted. It was observed that cinnamaldehyde with DHT treatment improved the POP–hydrogel CaCO3 properties and had good biocompatibility. Thus, POP-cinnamaldehyde-loaded CaCO3 hydrogel can be a promising bone substitute containing an anti-inflammatory agent.
Background: One of the efforts to prevent adhesion and biofilm colonization on the material surface is to improve its properties by using Titanium dioxide (TiO₂) nanoparticles. TiO₂ nanoparticles have antimicrobial properties, especially against the fungus Candida albicans as it has photocatalytic properties that can inhibit the growth of the fungal colonies. The present study aimed to determine the effect of applying TiO₂ to polyurethane plates on the growth of Candida albicans fungal biofilms.Methods: This study applied a laboratory experimental design. The subjects were divided into two groups which included the treatment and control groups. In the treatment group, there were two treatments consisting of the addition of TiO₂ filler (1%, 2%, 3%, and 4%) and the material surface coating group with TiO₂ (1%, 2%, 3%, and 4%). Candida albicans was cultured and grown to form biofilms on polyurethane plates in each group.Results: The results of the statistical analysis obtained through Welch's One Way Anova showed that there was a significant difference in the number of Candida albicans colonies between the treatment and control groups (P<0.05). Treatment with 4% TiO₂ surface coating showed the lowest number of Candida albicans colonies.Conclusions: Coating the surface of the material with TiO₂ on a polyurethane plate was able to inhibit the formation of Candida albicans biofilms.
Abstract. The aim of the present study was to develop the chitosan-gelatin membrane for cinnamaldehyde control release since it has a crosslinking effect. Porous membranes with differences cinnamaldehyde concentration as an antiinflammatory agent in the size of ±1.5x1.5 cm, 1 mm thickness and weight around 0.27 g were prepared for measure the swelling ratio and weight loss. Scanning electron microscopy was carried out to describe the surface structure, and the chemical bonding was investigated by Fourier Transformed Infrared (F-TIR). The one way ANOVA and LSD analysis of the swelling ratio and weight loss demonstrated that there were significant differences between all cinnamaldehyde groups and a control group (p<0.05).
ARTICLES YOU MAY BE INTERESTED INChitosan-gelatine membrane construct with different cinnamaldehyde concentration as drug delivery system in oral cavity AIP Conference Proceedings 1755, 160006 (2016) Abstract. Chitosan, a biocompatible and biodegradable polymer which has a potential use in drug delivery system. Cinnamaldehyde as an anti-inflammatory agent is suggested for wound healing application. However direct incorporation cinnamaldehyde to the formulation need more attention since its low water solubility and have a crosslinking effect like the other aldehyde group. The aim of this study was to evaluate the effect of different cinnamaldehyde concentration on the characterization of the chitosan-gelatin membrane as drug delivery system. Chitosan-gelatin membrane was prepared by mixing emulsion system that consists of cinnamaldehyde, polyethylene glycol 400 and virgin coconut oil with a homogenized chitosan-gelatin solution. Specimen was cut in 1.5X1.5cm for the cinnamaldehyde groups and control group. In this present study, chitosan-gelatin membrane incorporated with cinnamaldehyde at level 1%, 2% and 3% (v/v) were prepared to examine contact angle, surface roughness and folding endurance. The one way ANOVA and LSD result proved a significant difference only between cinnamaldehyde 3 % and control group on contact angle and surface roughness (p<0.05). The incorporation of cinnamaldehyde 3% into chitosangelatin membrane was found increasing the folding endurance significantly among the other groups (p<0,05).In conclusion, the result demonstrated that the chitosan-gelatin membrane is suitable for cinnamaldehyde delivery system.
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