These results indicate that TGF-beta-mediated processes could be responsible for localized lens capsular heterogeneity, establishing a substrate suitable for cell migration or the release of matrix-bound factors which influence the terminal differentiation of lens cells.
These results indicate that TGF-beta may have a normal function in the lens regulating capsular protein production. The potent stimulation of lens cell growth by TGF-beta may be due to mis-regulated production of lens capsular proteins not normally found in great abundance.
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