International audienceMeasurement of redox potential in fluoride media is a major problem due to the difficulty to design a reference electrode with high stability, high mechanical resistance and high accuracy. In the frame of molten salt reactor studies, a dynamic reference electrode (DRE) is developed to measure redox potential in fluoride molten salt at high temperature. DRE is based on the in-situ generation of a transient redox system. The choice of the redox couple corresponds to the cathodic limit of the molten salt considered. As a preliminary step, the demonstration of feasibility of generating a DRE was done in LiF-NaF-KF (46.5–11.5–42 mol%) media at 500 °C. In this salt, the reference redox system generated by coulometry at applied current is KF/K, metallic potassium being electrodeposited on a tungsten wire electrode. The validation of the DRE response and the experimental optimization parameters for DRE generation were realized by following the NiF2/Ni redox potential evolution as a function of NiF2 concentration in the fused salt.The current value applied for DRE generation was optimized. It depends on the amount of metallic cations contained in the fused salt and which can be electrochemically reduced simultaneously during the DRE generation. The current corresponding to the DRE generation has to be 4 times greater than the current corresponding to the reduction of the other elements

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The nuclear fuel reprocessing is a prerequisite for nuclear energy to be a clean and sustainable energy. In the case of the molten salt reactor containing a liquid fuel, pyrometallurgical way is an obvious way. The method for treatment of the liquid fuel is divided into two parts. In-situ injection of helium gas into the fuel leads to extract the gaseous fission products and a part of the noble metals. The second part of the reprocessing is performed by ‘batch’. It aims to recover the fissile material and to separate the minor actinides from fission products. The reprocessing involves several chemical steps based on redox and acido-basic properties of the various elements contained in the fuel salt. One challenge is to perform a selective extraction of actinides and lanthanides in spent liquid fuel. Extraction of actinides and lanthanides are successively performed by a reductive extraction in liquid bismuth pool containing metallic lithium as a reductive reagent. The objective of this paper is to give a description of the several steps of the reprocessing retained for the molten salt fast reactor (MSFR) concept and to present the initial results obtained for the reductive extraction experiments realized in static conditions by contacting LiF-ThF4-UF4-NdF3 with a lab-made Bi-Li pool and for which extraction efficiencies of 0.7% for neodymium and 14.0% for uranium were measured. It was concluded that in static conditions, the extraction is governed by a kinetic limitation and not by the thermodynamic equilibrium.

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Diabetes is characterized by increased levels of oxidative stress. Its suggested that extract of cupuaçu could improve the antioxidant system in diabetes. The aim was to evaluate the effect of EC on Nrf2/NF-κB p65 in normal and diabetic rats. Male, adult Wistar rats (9-week-old) were distributed in 4 groups: control (CTL) and diabetic (DM) who received water; CTLEC and DMEC who received 1 mL/day of EC (1 g/mL), via gavage for 8 consecutive weeks. The diabetes was inducted with a single intravenous dose of 45 mg/kg streptozotocin. Glycemia and body weight were measured at the beginning and end of the protocol, and the renal tissue was analyzed by Western blot for SOD-1, SOD-2, CAT, GSSG, Nrf2, NF-κB p65, iNOS and 3-NT. Glycemia was reduced in DMEC vs.DM after 8 weeks of EC treatment. There was no difference in body weight of DMEC vs. DM; however, DMEC vs. DM presented increased levels of CAT and Nrf2, with a significant reduction of NF-κB p65, iNOS and 3-NT. Therefore, we suggest that EC could be utilized as a complementary therapy to ameliorate the antioxidant profile via Nrf2 and to delay the evolution of diabetic complications in renal tissue by inflammatory pathway inhibition.

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