The aim of this dissertation is to identify evidences for which the recent Science, Technology and Innovation Policy of São Paulo State is incorporating regional development issues and what role it plays in the success of social and economic development in São Paulo regions. The literature review and empirical data converges to the identification of a new policy of Regional Development for Sao Paulo State and its microregions. This new policy has science, technology and innovation (STI) as its main tool. STI is capable for generating and adding value to productive sector and ensures appropriation of knowledge and income produced in the region. The main result of this dissertation is to identify the relationship between geographical proximity, the formation of human resources and knowledge generation, and the presence of the productive sector, as key variables for the success of regional development policies.
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