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AbstractThe use of codification to support knowledge transfer across projects has been explored in several recent, and mostly qualitative, studies. Building on that research, this paper puts forward hypotheses about the antecedents of knowledge codification, and tests them on a sample of 540 inter-organizational projects carried out in the creative, high-tech and engineering industries. We find that the presence of strong industry norms governing the division of labour discourages knowledge transfer through codification, as suggested by the existing qualitative studies. The presence of a system integrator plays an important role in driving the use of codification for knowledge transfer, to some extent embodying an organizational memory in volatile project environments. Finally, the level of use of administrative control in the project is a robust predictor of attempts to transfer knowledge via codification. When these antecedents are taken into account, the novelty of products and services plays a smaller role than previously found in determining the use of codification.
Based on the currently available clinical data, this analysis suggests that regorafenib is cost-effective compared with imatinib rechallenge in Germany.
New technological opportunities and online communication constantly gain importance for knowledge integration and knowledge creation in any innovation-driven environment. The cooperation between firms and individual actors in biotechnology was characteristically organized in local or regional clusters, based on face-to-face communications and strategic temporary linkages to other clusters. However, this archetypal configuration can change with the emerging use of open innovation models such as online research communities. A qualitative case study including an analysis of forums within an open source biomedical research platform portrays how knowledge integration mechanisms, and hence, innovations are implemented in virtual space. In this newly created environment, a number of geographical patterns are inverted: The strong role of physical co-location is partly substituted by enabled online proximity and new opportunities of virtual “prototype-sharing”; the former global pipelines are transformed to local and virtual cross-community pipelines. Yet mechanisms of creating social coherence and stability illustrate noteworthy similarities with “localized capabilities” of regional agglomerations. Eventually, knowledge integration capabilities ensure that the network can operate as a successful knowledge provider.
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