Quantification of PD-L1 expression is feasible on cytology specimens, and the results are comparable to those obtained from surgical resection and small biopsy specimens, including in matched specimens and using a single predictive IHC marker. Future studies will be necessary to determine the comparative value of other antibodies and their ability to predict response to immunotherapy. Cancer Cytopathol 2017;125:896-907. © 2017 American Cancer Society.

We construct the moduli spaces of stable maps, Mg,n(P r , d), via geometric invariant theory (GIT). This construction is only valid over Spec C, but a special case is a GIT presentation of the moduli space of stable curves of genus g with n marked points, Mg,n; this is valid over Spec Z. In another paper by the first author, a small part of the argument is replaced, making the result valid in far greater generality. Our method follows that used in the case n = 0 by Gieseker in [7], to construct Mg , though our proof that the semistable set is nonempty is entirely different.Proof. IfJ ss (L) = J, thenJ// L SL(W ) is a categorical quotient of J, and if J ss (L) =J s (L), the quotient is an orbit space. The result follows from Proposition 3.4 and Proposition 2.3.In the following GIT construction, we will first seek a linearisation L such that J ss (L) ⊂ J. This has many useful implications, which we shall explore now. In particular, it gives us the first half of the desired equality:J ss (L) =J s (L).Proposition 3.6. Suppose there exists a linearisation L such thatJ ss (L) ⊆ J. ThenJ ss (L) =J s (L).Proof. Every point of J corresponds to a moduli stable map, and so has finite stabiliser. The result follows from Corollary 2.6. This leaves us with the second required equality, thatJ ss = J. In this paper, we shall prove it using the existing construction of M g,n (P r , d) over C, given by Fulton and Pandharipande in [6]. This is not necessary (see [2]), but for brevity we take this shortcut for now.Corollary 3.7. There exists a map j : J → M g,n (P r , d), which is an orbit space for the SL(W ) action, and in particular a categorical quotient. The morphism j is universally closed.

We study a family of semi-ample divisors on the moduli space of n-pointed genus 0 curves given by higher-level conformal blocks. We derive formulae for their intersections with a basis of 1-cycles, show that they form a basis for the Sn-invariant Picard group, and generate a full-dimensional subcone of the Sn-invariant nef cone. We find their position in the nef cone and study their associated morphisms.

ROSE with appropriate triage, including performing a dedicated pass and proper slide preparation, improves MT, and this is enhanced by having >1 cytologist at the start of the procedure. In the era of personalized medicine, "adequate" should denote sufficient tissue for diagnosis and MT.

We study a family of semiample divisors on the moduli space M0,n that come from the theory of conformal blocks for the Lie algebra sln and level 1. The divisors we study are invariant under the action of Sn on M0,n. We compute their classes and prove that they generate extremal rays in the cone of symmetric nef divisors on M0,n. In particular, these divisors define birational contractions of M0,n, which we show factor through reduction morphisms to moduli spaces of weighted pointed curves defined by Hassett.