Poly(vinyl
chloride) (PVC) is the most used biomedical polymer
worldwide. PVC is a stable and chemically inert polymer. However,
microorganisms can colonize PVC producing biomedical device-associated
infections. While surface modifications of PVC can help improve the
antimicrobial and antiviral properties, the chemically inert nature
of PVC makes those modifications challenging and potentially toxic.
In this work, we modified the PVC surface using a derivative riboflavin
molecule that was chemically tethered to a plasma-treated PVC surface.
Upon a low dosage of blue light, the riboflavin tethered to the PVC
surface became photochemically activated, allowing for Pseudomonas aeruginosa bacterial biofilm and lentiviral
in situ eradication.
In this study, micro-engineered chitosan substrates were employed to investigate the compounded effects of topography, roughness and stiffness on the response of DRGs and hMSCs.
This review provides a comprehensive compendium of commonly used biomaterials as well as the different fabrication techniques employed for the design of 3D neural tissue models.
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