In a companion paper by Koposov et al., RR Lyrae from Gaia Data Release 2 are used to demonstrate that stars in the Orphan stream have velocity vectors significantly misaligned with the stream track, suggesting that it has received a large gravitational perturbation from a satellite of the Milky Way. We argue that such a mismatch cannot arise due to any realistic static Milky Way potential and then explore the perturbative effects of the Large Magellanic Cloud (LMC). We find that the LMC can produce precisely the observed motiontrack mismatch and we therefore use the Orphan stream to measure the mass of the Cloud. We simultaneously fit the Milky Way and LMC potentials and infer that a total LMC mass of 1.38 +0.27 −0.24 × 10 11 M is required to bend the Orphan Stream, showing for the first time that the LMC has a large and measurable effect on structures orbiting the Milky Way. This has far-reaching consequences for any technique which assumes that tracers are orbiting a static Milky Way. Furthermore, we measure the Milky Way mass within 50 kpc to be 3.80 +0.14 −0.11 × 10 11 M . Finally, we use these results to predict that, due to the reflex motion of the Milky Way in response to the LMC, the outskirts of the Milky Way's stellar halo should exhibit a bulk, upwards motion.

We use astrometry, broad-band photometry and variability information from the Data Release 2 of ESA's Gaia mission (GDR2) to identify members of the Orphan Stream (OS) across the whole sky. The stream is traced above and below the celestial equator and in both Galactic hemispheres, thus increasing its visible length to ∼ 210 • equivalent to ∼ 150 kpc in physical extent. Taking advantage of the large number of RR Lyrae stars in the OS, we extract accurate distances and proper motions across the entire stretch of the tidal debris studied. As delineated by the GDR2 RR Lyrae, the stream exhibits two prominent twists in its shape on the sky which are accompanied by changes in the tangential motion. We complement the RR Lyrae maps with those created using GDR2 Red Giants and the DECam Legacy Survey Main Sequence Turn-Off stars. The behavior of the OS track on the sky is consistent across all three tracers employed. We detect a strong non-zero motion in the across-stream direction for a substantial portion of the stream. Such a misalignment between the debris track and the streaming velocity cannot be reproduced in a static gravitational potential and signals an interaction with a massive perturber.

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and the Israel Cytokines Standardization Laboratory.Background. The study aim was to determine the kinetics of serum pro-and anti-inflammatory cytokines and C-reactive protein (CRP) in hip-fracture patients over a month postfracture, and their relationship to postoperative (postop) complications and cognitive level.

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