Asp 1,p-fluoro-L-phenylalanine 4]-angiotensin 11 ([pFPhe +AII) and [Asp 1,p-fluoro-~-phenylalanine81-angiotensin I1 ([pFPhe*]-AII) were synthesized by the solid-phase procedure in order to study their biological activity and I9F nuclear magnetic resonance (nmr) spectra. p-Fhoro-D,Lphenylalanine was resolved by enzymatic hydrolysis of Ntrifluoroacetyl-p-fluoro-~,~-phenylalanine with carboxypeptidase A. [pFPhe*]-AI1 is at least as potent as angiotensin I1 and [pFPhe4]-AI1 is an antagonist of angiotensin I1 in the T he replacement of hydrogen by fluorine has become a useful tool for pharmacological and structural analysis of organic compounds. The similarity of van der Waals' radii t From the
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