For a variety of reasons, the management of brain tumors, both primary and metastatic, remains a considerable challenge. As most systemic therapies do not cross the BBB at therapeutic doses, radiation and surgery have played primary roles in the management of these diseases. Despite significant advances in surgical techniques and radiation delivery, outcomes for most adult brain tumors continue to be poor. In an effort to enhance the effects of radiation in the brain, a variety of radiation sensitizers, including motexafin gadolinium, have been investigated. In the following manuscript, we summarize motexafin gadolinium and its role in brain tumors.
The ‘Theory of Mind’ approach has been associated with probably the fastest-growing body of empirical research in psychology over the last 25 years, and has given rise to a range of different theoretical positions and elaborations within those positions. The basic idea is that understanding other people involves bridging a gulf between observed ‘behaviour’ and hidden mental states by means of a theory. The articles in this Special Issue subject ‘Theory of Mind’ to sustained critical scrutiny, and also present alternative accounts of how we make sense of—and make sense to—other people. They trace the historical sources of ‘Theory of Mind’, criticize its fundamental assumptions and favoured methods, and examine its applications to child development and the explanation of schizophrenia and autism.
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