No abstract

Objective:The primary objective of this study is to examine the medication adherence levels (as a function of pharmaceutical care) and its contributing factors in schizophrenic patients receiving antipsychotic drugs.Methods:This was a cross-sectional study administering a structured questionnaire to 231 patients. Adherence was measured through patient self-reporting. Association between independent variables and adherence to antipsychotics were measured through odds ratios (OR) in the univariate analysis while the best predictors of adherence were determined through the multiple logistic regressions.Findings:Adherence level was found to be 65.8% (95% confidence interval [CI]: 59.3-71.9%). The following factors were identified to be associated with adherence in the univariate analysis: age (OR 1.088), sex (OR 1.231), employment (OR 0.366), marital status (singles, OR 0.022), drug adherence counseling (OR 11.641), twice a day frequency (OR 8.434), alcohol non-intake (OR 1.469), educational level (primary OR 1.9312, secondary OR 11.022, tertiary OR 4.771), occupation (public servant 6.273). In the multivariate analysis, age, three times a day frequency of drug intake, singles and educational levels such as primary, secondary or tertiary school, strongly affected adherence (P < 0.05).Conclusion:Although patients adherence level was high (65.8%), there is a need to emphasize that pharmacists spend more time in counseling and educating patients, especially younger ones on drug adherence before any antipsychotic medications are dispensed. Furthermore, patients should be taught the use of adherence devices such as reminders so that adherence to antipsychotic medications can be optimized.

Background: Despite close to two decades of antiretroviral therapy (ART) in Nigeria, data on late on-onset ART-associated adverse drug reactions (ADRs) are sparse. Objectives: To describe early and late-onset ADRs and compare their incidence in an outpatient HIV positive Cohort on ART. Method: We described the incidence of clinical ADRs identified and documented in an outpatient clinic cohort of HIV-pos- itive patients treated between June 2004 and December 2015 at a tertiary health facility in Nigeria. Incidence rates of ADRs during the first and subsequent years of ART were compared. Results: of the 13,983 patients’ data analyzed, 9317 were females (66%), and those in the age bracket of 25 to 45 years made up 78% of the studied population. During 52,411 person-years (py) of ART, 1485 incident ADRs were recorded; Incidence rate (IR) 28.3 (95% confidence interval [CI] 26.9:29.8) ADRs per 1000 person-years (py) of ART. The IR of ADRs was about two times higher in the first year of ART compared to subsequent years of treatment; crude incidence rate ratio (IRR) 1.77 (95% CI 1.59:1.97). Anemia, hypersensitivity reactions, and nervous system disorders had 7, 23, and 5 times higher incidence, respectively, in the first year of therapy, compared to subsequent years. Conclusion: The first year of ART is the period of highest risk of ADRs. Individual and programmatic treatment success in resource-limited settings requires strategies for early identification and management of ADR during the period of greatest risk of ADRs. Keywords: Adverse drug events; antiretroviral therapy; drug toxicity; sub- Saharan Africa.

The present study assessed the dimensionality and item difficulty targeting to person ability of HKAPIUM scale using Rasch Wright map approach. A HKAPIUM instrument (Cronbach’s alpha = 0.71) containing eighteen (18)-items was administered to 121 trained healthcare professionals involved in the management of uncomplicated malaria in 24 selected primary health care (PHC) facilities in Plateau state, Nigeria. The respondents filled and returned the instrument and the data was analyzed using Bond&Fox software®. The Rasch principal components analysis (Rasch-PCA) of the item residuals indicated variance explained values of 52 (knowledge), 41.1 (attitudes), and 55.4 (practices) and eigenvalues of the first contrast as 1.2, 1.8, and 1.5, respectively, which were within acceptable values thatindicated the unidimensionality of the three constructs of the HKAPIUM scale. The result showed moderate items difficulty levels for all the three constructs. The mean person ability levels of respondents with-respect-to knowledge-related items were low, while their mean person ability levels in endorsing the attitudes and practices-related items were good. The study revealed unidimensionality of the 3 constructs of HKAPIUM scale, with observed mismatch between item difficulty levels of the constructs with most of the person ability levels of the respondents.

With a prevalence rate of 3.1%, Nigeria has a generalized HIV/AIDS epidemic. Like much other developing countries, Nigeria has to collaborate with development partners to fight the HIV/AIDS scourge. This review assesses the impact of foreign aid initiatives on the fight against HIV/AIDS in Nigeria. It examines Nigeria's capacity and willingness to independently own a sustainable provision of HIV/AIDS care in the country. This paper assesses the outcomes of the HIV/AIDS scheme. Our review indicates that foreign aid initiatives were responsible for the rapid scale-up in HIV/AIDS services and improvement in morbidity and mortality rates. While foreign aids have