Aim and Objective: In the work, we have successfully presented a synthetic route for the synthesis of novel 2',4'-dihydrospiro[chroman-2,3'-pyrazol]-4-one derivatives via one pot multicomponent approach. Materials and Method: Substituted 2',4'-dihydrospiro[chroman-2,3'-pyrazol]-4-one were prepared through cascade three-component condensation of ortho-hydroxyacetophenone, β-ketoester, hydrazine in the presence of pyrrolidine as a catalyst under ethanol reflux conditions. Results: A series of novel 2',4'-dihydrospiro[chroman-2,3'-pyrazol]-4-one have been synthesized through a facile strategy. These structures of newly synthesized derivatives were determined by 1H, 13C NMR, HRMS and CHNS analysis. Conclusion: We have achieved the one-pot, three-component synthesis of highly substituted pyrazole spirochromanones in presence of pyrrolidine as a catalyst under ethanol reflux conditions. Using different types of aliphatic and aromatic β-ketoesters, o-hydroxyacetophenone derivatives and different kinds of hydrazine derivatives as building blocks, we could construct novel libraries of substituted pyrazole spirochromanones that make this method suitable for combinatorial and parallel synthesis in drug discovery.

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Expanded requirement for the lanthanides in industrial stuff resulted in intensified manufacture of lanthanide containing ores. This increases public contact to the lanthanides, both from production wastes/effluents and from various commercial products. Present study describes the efficacy of γ-Fe2O3 (nano maghemite) for fast adsorption of some of the long-lived, toxic and radioactive human made radio nuclides from natural waters. Nanometal oxides have been successfully prepared by precipitation synthesis followed by thermal decomposition of transition metal oxides, These are further characterized by different physico-chemical techniques like XRD, UV-Vis-DRS, TEM, FTIR and BET analysis. Adsorption capacities of REEs like La(III), and Nd(III) are observed through ICPAES technique. The parameters influencing the adsorption capacity, which includes pH, contact time, initial concentration, and temperature are optimized. The adsorption kinetics and thermodynamics are analysed. These results proved that nanometal oxide (γ-Fe2O3) have been successfully prepared by precipitation synthesis followed by thermal decomposition of transition metal oxides, and followed a novel method to mollify the seriousness of nuclear waste contamination, which leads to successful evaluation for environmental problems.