We present a CMOS imager consisting of 32×32 smart pixels, each one able to detect single photons in the 300-900 nm wavelength range and to perform both photon-counting and photon-timing operations on very fast optical events with faint intensities. In photon-counting mode, the imager provides photon-number (i.e, intensity) resolved movies of the scene under observation, up to 100 000 frames/s. In photon-timing, the imager provides photon arrival times with 312 ps resolution. The result are videos with either time-resolved (e.g., fluorescence) maps of a sample, or 3-D depth-resolved maps of a target scene. The imager is fabricated in a cost-effective 0.35-μm CMOS technology, automotive certified. Each pixel consists of a single-photon avalanche diode with 30 μm photoactive diameter, coupled to an in-pixel 10-bit time-to-digital converter with 320-ns full-scale range, an INL of 10% LSB and a DNL of 2% LSB. The chip operates in global shutter mode, with full frame times down to 10 μs and just 1-ns conversion time. The reconfigurable imager design enables a broad set of applications, like time-resolved spectroscopy, fluorescence lifetime imaging, diffusive optical tomography, molecular imaging, time-of-flight 3-D ranging and atmospheric layer sensing through LIDAR

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Single-photon avalanche diodes (SPADs) emerged as the most suitable photodetectors for both single-photon counting and photon-timing applications. Different complementary metal-oxide-semiconductor (CMOS) devices have been reported in the literature, with quite different performance and some excelling in just few of them, but often at different operating conditions. In order to provide proper criteria for performance assessment, we present some figures of merit (FoMs) able to summarize the typical SPAD performance (i.e., photon detection efficiency, dark counting rate, afterpulsing probability, hold-off time, and timing jitter) and to identify a proper metric for SPAD comparisons, when used either as single-pixel detectors or in imaging arrays. The ultimate goal is not to define a ranking list of best-in-class detectors, but to quantitatively help the end-user to state the overall performance of different SPADs in either photon-counting, timing, or imaging applications. We review many CMOS SPADs from different research groups and companies, we compute the proposed FoMs for all them and, eventually, we provide an insight on present CMOS SPAD technologies and future trends

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We present a single-photon avalanche diode (SPAD) front-end circuitry, in a cost-effective 0.35 μm CMOS technology, for single-photon detection in the visible wavelength range, aimed at speeding up the sensing of detector ignition and at promptly quenching the avalanche current buildup. The circuit allows the reduction in detrimental effects of afterpulsing through reducing any delays in the electronics intervention on the detector and through a proper time-varying action of the MOS transistors on the different SPAD’s operating conditions. The sensing time is reduced down to a few hundreds of picoseconds, with an active quenching transition of about 1 ns for 6 V excess bias, and a final reset in just 3 n

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Laser speckle contrast imaging (LSCI) has emerged as a valuable tool for cerebral blood flow (CBF) imaging. We present a multi-exposure laser speckle imaging (MESI) method which uses a high-frame rate acquisition with a negligible inter-frame dead time to mimic multiple exposures in a single-shot acquisition series. Our approach takes advantage of the noise-free readout and high-sensitivity of a complementary metal-oxide-semiconductor (CMOS) single-photon avalanche diode (SPAD) array to provide real-time speckle contrast measurement with high temporal resolution and accuracy. To demonstrate its feasibility, we provide comparisons between in vivo measurements with both the standard and the new approach performed on a mouse brain, in identical conditions.

We present an optical 3-D ranging camera for automotive applications that is able to provide a centimeter depth resolution over a mbox{40}^{\circ} \times mbox{20}^{\circ} field of view up to 45 m with just 1.5 W of active illumination at 808 nm. The enabling technology we developed is based on a CMOS imager chip of 64 \times 32 pixels, each with a single-photon avalanche diode (SPAD) and three 9-bit digital counters, able to perform lock-in time-of-flight calculation of individual photons emitted by a laser illuminator, reflected by the objects in the scene, and eventually detected by the camera. Due to the SPAD single-photon sensitivity and the smart in-pixel processing, the camera provides state-of-the-art performance at both high frame rates and very low light levels without the need for scanning and with global shutter benefits. Furthermore, the CMOS process is automotive certified