Author Contributions: Mr Kodumudi had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
A 55-year old woman presented with a 6-week history of an enlarging, tender, pruritic, 4-cm erythematous patch with central inflammatory papules distributed on the medial forehead (Figure , A). No inciting events, such as arthropod bite or trauma, were noted. She was initially treated for presumed shingles with valacyclovir, cephalexin, gabapentin, and hydrocortisone 2.5% topical ointment with no improvement in appearance or symptoms. No other cutaneous abnormalities were noted. A punch biopsy specimen of the left medial forehead was obtained, and histological and immunohistochemical analyses were performed (Figure , B and C).
Diagnosis
B. Angiosarcoma9. Florou V, Rosenberg AE, Wieder E, et al. Angiosarcoma patients treated with immune checkpoint inhibitors: a case series of seven patients from a single institution.
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