Prescription drug misuse and suicidal ideation: Findings from the National Survey on Drug Use and Health

Ford, Jason A.; Perna, Danielle

doi:10.1016/j.drugalcdep.2015.10.010

Cited by 23 publications

(31 citation statements)

References 30 publications

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“…This finding is consistent with past work linking opioid PDM to suicidal ideation in adolescents and adults (Ford & Perna, 2015; Guo et al, 2016; Zullig & Divin, 2012). The current work adds to the literature by linking tranquilizer/sedative PDM to suicidal ideation across the population, further highlighting the risk of such PDM, not least because of the overdose potential inherent in tranquilizer/sedative medication (Warner, Trinidad, Bastian, Minino, & Hedegaard, 2016).…”

Section: Discussionsupporting

confidence: 92%

Prescription tranquilizer/sedative misuse prevalence and correlates across age cohorts in the US

Schepis

Teter

Simoni

et al. 2018

Addictive Behaviors

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This work highlighted young adults and those with other substance use as most likely to engage in tranquilizer/sedative misuse. In particular, those endorsing suicidality and reporting opioid misuse are a subgroup of concern, given their especially elevated rates of misuse and the increased risk for overdose imparted by tranquilizer/sedative medication. Workplace-based interventions for young adults and school-based universal prevention may be warranted to limit tranquilizer/sedative misuse in these groups.

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Section: Discussionsupporting

confidence: 92%

Prescription tranquilizer/sedative misuse prevalence and correlates across age cohorts in the US

Schepis

Teter

Simoni

et al. 2018

Addictive Behaviors

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“…We hypothesized that after controlling for sociodemographic, physical health, mental health, and substance use of past-year suicidal ideation, past-year use without misuse of either opioids or benzodiazepines would not be associated with suicidal ideation but that misuse of either opioids or benzodiazepines would be associated with suicidal ideation, given past work across the population. 20…”

Section: Aims and Hypothesesmentioning

confidence: 99%

“…In adolescents, both cross‐sectional and longitudinal evidence link opioid and benzodiazepine PDM with suicidal ideation. Work across the US adult population also supports a link between opioid PDM and suicidal ideation . While opioid‐related mortality rates rose among US older adults from 2006 to 2013, it is not clear that these increased rates were from intentional misuse.…”

Section: Introductionmentioning

confidence: 99%

“…The primary aims of this work were to evaluate whether past‐year prescription opioid and benzodiazepine use without misuse or misuse were associated with past‐year suicidal ideation in US older adults (aged 50 and older). We hypothesized that after controlling for sociodemographic, physical health, mental health, and substance use of past‐year suicidal ideation, past‐year use without misuse of either opioids or benzodiazepines would not be associated with suicidal ideation but that misuse of either opioids or benzodiazepines would be associated with suicidal ideation, given past work across the population …”

Section: Introductionmentioning

confidence: 99%

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Prescription opioid and benzodiazepine misuse is associated with suicidal ideation in older adults

Schepis

Simoni

McCabe

2018

Int J Geriat Psychiatry

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Objectives: Suicide in older adults is a major public health issue. Past research across the US adult population has linked prescription medication misuse with suicidal ideation. No work has evaluated associations between prescription opioid or benzodiazepine misuse and suicidal ideation in older adults, and this work aimed to address that gap. Methods/Design: Data were from adults 50 years and older participating in the 2015-16 National Survey on Drug Use and Health (n = 17,608). Design-based logistic regression evaluated links between any past-year prescription opioid or benzodiazepine use without misuse or prescription misuse and past-year suicidal ideation, after controlling for sociodemographic, physical health, mental health and substance use correlates associated with suicidal ideation. Results: After controlling for all correlates, past-year use without misuse of prescription opioids or benzodiazepines were not associated with past-year suicidal ideation in older adults. In contrast, past-year opioid misuse (AOR = 1.84, 95% CI = 1.07-3.19) and benzodiazepine misuse (AOR = 2.00, 95% CI = 1.01-3.94) were significantly associated with past-year suicidal ideation, even after controlling for all covariates. While 2.2% of US older adults not engaged in either opioid or benzodiazepine misuse reported past-year suicidal ideation, 25.4% of those who misused both medication classes endorsed such suicidality (AOR = 4.73, 95% CI = 2.07-10.79). Conclusions: Both past-year prescription opioid and benzodiazepine misuse are associated with past-year suicidal ideation in US older adults. Clinicians encountering older adult patients at-risk for or engaged in prescription medication misuse also should screen for suicidality.

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“…Although numerous studies provide evidence for a relation between opioid misuse and suicidal ideation both within the general population (Ashrafioun et al., ; Ford & Perna, ; Kuramoto et al., ) and among opioid‐dependent individuals (Thompson et al., ), the literature on the relation between opioid misuse and suicide attempts is less clear. For example, although some studies report elevated rates of suicide attempts among individuals with opioid dependence (Maloney, Degenhardt, Darke, Mattick, & Nelson, ; Trémeau et al., ), others have reported nonsignificant associations between opioid use or dependence and suicide attempts (Kuramoto et al., ).…”

mentioning

confidence: 99%

The Role of Opioid Use in Distinguishing between Suicidal Ideation and Attempts

Anestis

Tull

Butterworth

et al. 2019

Suicide & Life Threat Behav

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Objective Opioid use disorders are associated with heightened suicidal ideation, suicide attempts, and suicide death. This study aimed to examine the extent to which opioid differentiates between those with suicide attempts from those with lifetime suicidal ideation but no history of attempt. Methods Participants were drawn from the US National Guard and a residential substance use treatment facility. Multinomial logistic regression was utilized to determine the extent to which a lifetime history of nonmedical opioid use differentiated between (1) individuals with no lifetime history of suicidal ideation or attempt, (2) individuals with a history of suicidal ideation but no attempt, and (3) individuals with a history of at least one suicide attempt. Results History of opioid use among National Guard personnel and opioid use disorders among substance‐dependent patients were associated with an increased likelihood of having at least one suicide attempt relative to both a history of suicidal ideation but no attempts and no history of ideation or attempts. Findings held when accounting for lifetime nonmedical use of other substances and the presence of other lifetime substance use disorders. Conclusions Results highlight the importance of assessing for suicide risk among opioid users.

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Prescription drug misuse and suicidal ideation: Findings from the National Survey on Drug Use and Health

Cited by 23 publications

References 30 publications

Prescription tranquilizer/sedative misuse prevalence and correlates across age cohorts in the US

Prescription tranquilizer/sedative misuse prevalence and correlates across age cohorts in the US

Prescription opioid and benzodiazepine misuse is associated with suicidal ideation in older adults

The Role of Opioid Use in Distinguishing between Suicidal Ideation and Attempts

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