Three types of hereditary angioedema (HAE) have been described: two are due to C1 inhibitor (C1-INH) deficiency (C1-INH-HAE types I and II) and one is characterized by normal C1-INH (nC1-INH-HAE). The management of pregnancy in patients with HAE is often a clinical challenge owing to potential worsening of the disease in relation to the physiological increase in estrogens and the limited treatment options. This review addresses the potential influence of pregnancy on the clinical severity of hereditary angioedema and the management of this disease during pregnancy with currently available treatments.

Palabras clave: Esofagitis eosinofílica. Diagnóstico por componentes. Perfil de sensibilización. Reactividad cruzada. Proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE) and eosinophilic esophagitis (EoE) are clinically undistinguishable entities [1-3]. Component-resolved diagnosis enables simultaneous assessment of specific IgE antibodies to various allergens and could provide us with more accurate information about sensitization profiles in these patients [4-6]. The aim of this study was to compare the molecular sensitization profiles of patients diagnosed with EoE and PPI-REE. We performed a retrospective cross-sectional study. The study population comprised patients followed up at the Allergy