Molecular Sensitization Profile According to Proton Pump Inhibitor Response in Patients With Esophageal Eosinophilia

Abstract

Palabras clave: Esofagitis eosinofílica. Diagnóstico por componentes. Perfil de sensibilización. Reactividad cruzada. Proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE) and eosinophilic esophagitis (EoE) are clinically undistinguishable entities [1-3]. Component-resolved diagnosis enables simultaneous assessment of specific IgE antibodies to various allergens and could provide us with more accurate information about sensitization profiles in these patients [4-6]. The aim of this study was to compare the molecular sensitization profiles of patients diagnosed with EoE and PPI-REE. We performed a retrospective cross-sectional study. The study population comprised patients followed up at the Allergy

Are the Proton Pump Inhibitor–Responsive and –Nonresponsive Phenotypes of Eosinophilic Esophagitis Exactly the Same?

“…Although not all experts agree, recent and evolving evidence, mostly from adults, shows that PPI-REE and EoE patients are clinically, endoscopically and histologically indistinguishable, with features of Th2 immune-mediated inflammation and gene expression [3].A Spanish study concludes that, both phenotypes of EoE share sensitization profiles with only slight differences [4] There are few any studies on whether both phenotypes (R-EoE and NR-EoE), are identical in allergic characteristics (ACh) and atopic comorbidities (AC). The objectives of this study were to study the similarities and differences between both phenotypes regarding the ACh and AC.…”