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We investigated effects of a Mediterranean‐style low glycemic load diet, with or without a soy protein, plant sterol‐(SPS) supplement, on cardiometabolic risk factors in 8 women with metabolic syndrome (MetS). Subjects had high plasma triglycerides (TG) (163.5 ± 59.1 mg/dL), elevated body mass index (31.0 ± 3.5 kg/m2), total body fat of 39 ± 4.9 kg, total trunk fat of 20.7 ± 2.9 kg, and plasma LDL of 107.1 ± 31.8 mg/dL. The 8‐week intervention diet provided an average energy distribution of 30:45:25 fat:carbohydrate:protein. Five subjects were randomly allocated to the SPS supplement. Compared to baseline, dietary protein intake increased (P<0.005), while added sugar and saturated fat decreased at 8 wks. Glycemic index decreased from 62.1 ± 5.4 to 48.8 ± 8.9 (P < 0.01) and glycemic load from 111.3 ± 34.2 to 50.1 ± 27.8 (P < 0.005). All subjects experienced significant reductions in body weight (5%; P < 0.001), total body fat (9%; P < 0.005), trunk fat (12%; P < 0.005), and in both systolic (P < 0.01) and diastolic (P < 0.05) blood pressure. Waist circumference decreased from 93.5 ± 3.9 to 88.3 ± 3.6 cm (P < 0.01). Plasma TG were reduced by 33% (P < 0.002) and total cholesterol from 203.6 ± 33.6 to 171.0 ± 44.5 mg/dL (P < 0.05). The intervention resulted in significant health benefits on all MetS parameters, mainly by reducing trunk fat and alleviating dyslipidemias. [Supported by Metagenics Inc., Gig Harbor, WA]