4B.05

Canivell, Sílvia; Ponte, Bauer; Pruijm, Menno; Ackermann, Daniela; Guessous, Idris; Ehret, Georg; Paccaud, F.; Péchère-Bertschi, Antoinette; Mohaupt, MG; Vogt, Bruno; Burnier, Michel; Devuyst, Olivier; Martin, Pierre Yves; Bochud, Murielle

doi:10.1097/01.hjh.0000467489.06977.50

Cited by 3 publications

(1 citation statement)

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“…In this study, increased SGU was associated with increased fasting glucose and total cholesterol, which is similar to the metabolic risk of copeptin. Copeptin is derived from the arginine vasopressin precursor and is a marker of vasopressin, which is positively correlated with insulin resistance, obesity, metabolic syndrome, and diabetes mellitus [27–32]. Increased copeptin has a deleterious effect in individuals who have conditions such as diabetic nephropathy and salt-sensitive hypertension [12].…”

Section: Discussionmentioning

confidence: 99%

Sub-morbid dehydration-associated glomerular hyperfiltration: An emerging reality?

Min

Sung

Lee

et al. 2019

Kidney Res Clin Pract.

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Background Severe dehydration decreases renal perfusion. However, it is unclear whether sub-morbid dehydration affects kidney function similarly. Although there have been numerous animal and human studies that have suggested mild dehydration is associated with glomerular hyperfiltration, it has not been confirmed on a large-scale in the general population. Therefore, we aimed to identify the relationship between hydration status and kidney function. Methods We reviewed the data of 28,342 adults who participated in the Korea National Health and Nutrition Examination Surveys. Urine specific gravity unit (SGU) was the primary variable that indicated hydration status, and the estimated glomerular filtration rate (eGFR) was used as the primary outcome. Results Multivariate linear regression analysis showed urine SGU was positively associated with eGFR, which was J-shaped in the multivariate generalized additive model plot. In the penalized spline curve analysis, the odds ratio for high eGFR was steadily increased. Although increased urine SGU was associated with decreased blood pressure and pulse rate, it had no effect on increased fasting glucose and total cholesterol, suggesting conflicting cardio-metabolic dehydration effects. Conclusion Dehydration, presumably sub-morbid in an ambulatory community-dwelling general population, is associated with higher kidney function. The clinical significance of sub-morbid dehydration-associated glomerular hyperfiltration needs further investigation.

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Section: Discussionmentioning

confidence: 99%

Sub-morbid dehydration-associated glomerular hyperfiltration: An emerging reality?

Min

Sung

Lee

et al. 2019

Kidney Res Clin Pract.

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Atrial natriuretic peptide, copeptin and adrenomedullin levels in polycystic ovary syndrome: a case-control study

Frøssing¹,

Nylander

Aziz

et al. 2016

Gynecological Endocrinology

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Acute and chronic hyperglycemic effects of vasopressin in normal rats: involvement of V_1A receptors

Taveau

Chollet

Bichet

et al. 2017

American Journal of Physiology-Endocrinology and Metabolism

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Recent epidemiological studies have revealed novel relationships between low water intake or high vasopressin (AVP) and the risk of hyperglycemia and diabetes. AVP V and V receptors (R) are expressed in the liver and pancreatic islets, respectively. The present study was designed to determine the impact of different levels of circulating AVP on glucose homeostasis in normal Sprague-Dawley rats, as well as the respective roles of VR and VR. We showed that acute injection of AVP induces a dose-dependent increase in glycemia. Pretreatment with a selective VR antagonist, but not a VR antagonist, dose-dependently prevented the rise in glycemia. VR antagonism did not modify the hyperinsulinemic response, resulting from AVP-induced hyperglycemia, but enhanced the fall in glucagonemia. Acute administration of selective VR or VR agonists confirmed the involvement of VR in the hyperglycemic effect of AVP. In chronic experiments, AVP levels were altered in both directions. Sustained AVP infusion through implantable minipumps induced a time-dependent increase in fasting glycemia, whereas lowering endogenous AVP by increasing water intake had no effect. After 4 wk of AVP infusion, the rise in glycemia amounted to 1.1 mmol/l ( < 0.01) without significant change in insulinemia. This effect was attenuated by cotreatment with a VR antagonist. Similar results were observed in lean Zucker rats. These findings demonstrate for the first time a causal link between chronic high AVP and hyperglycemia through VR activation and, thus, provide a pathophysiological explanation for the relationship observed in human cohorts between the AVP-hydration axis and the risk of diabetes.

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4B.05

Cited by 3 publications

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Sub-morbid dehydration-associated glomerular hyperfiltration: An emerging reality?

Sub-morbid dehydration-associated glomerular hyperfiltration: An emerging reality?

Atrial natriuretic peptide, copeptin and adrenomedullin levels in polycystic ovary syndrome: a case-control study

Acute and chronic hyperglycemic effects of vasopressin in normal rats: involvement of V_1A receptors

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4B.05

Cited by 3 publications

References 0 publications

Sub-morbid dehydration-associated glomerular hyperfiltration: An emerging reality?

Sub-morbid dehydration-associated glomerular hyperfiltration: An emerging reality?

Atrial natriuretic peptide, copeptin and adrenomedullin levels in polycystic ovary syndrome: a case-control study

Acute and chronic hyperglycemic effects of vasopressin in normal rats: involvement of V1A receptors

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Acute and chronic hyperglycemic effects of vasopressin in normal rats: involvement of V_1A receptors