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T his paper evaluates the economic advantages and disadvantages of the Eastern expansion of the European Union for old and new EU member states, and introduces support programmes which aim to integrate regions on both sides of the border. It focuses especially on the development of cross-border scientific cooperation between Germany and Poland. An empirical study on the example of the Europa University Viadrina (EUV), a newly founded university in the German-Polish border region, shows the extent of German-Polish cooperation based on co-publication activity. In our