Introduction: Central giant-cell granulomas (CGCL) are benign, but occasionally ag- gressive, lesions that traditionally have been treated surgically. Nonsurgical treatments, such as intralesional corticosteroid injections, systemic calcitonin and interferon have been reported. The advantages of this therapy include its less-invasive nature, the pro- bable lower cost to the patient and the preservation of important structures. Objectives: This paper aims to report a case of a pediatric patient with CGCL of the jaw, which was successfully treated with intralesional corticosteroid injections as it’s only therapy and discuss if there is an ideal waiting period between nonoperative treatment and the need for surgical intervention. Methods and Materials: an eight-year-old boy with a central giant cell lesion on the right side of the mandible was treated with intralesional corticos- teroids injections. Results and Conclusion: After an eight-year follow-up, the patient’s bony architecture was near normal. The panoramic radiography showed areas of new bone formation and neither recurrence nor side effects of the medication have been also detected. Is there an ideal waiting period between nonoperative treatment and the need for surgical intervention? It is estimated that a monitoring period of 6-8 years is necessary to determine the success of such treatment.
BackgroundThe effects of extracellular dehydration on the urinary bladder reactivity.AimTo investigate if different extracellular dehydration models affect urinary bladder reactivity to vasopressin and neurotransmitters of the autonomic nervous system in female Wistar rats.MethodsAdult female Wistar rats (N=6/group) one group the animals were in water deprivation for 24 hours and another group received a furosemide injection (50,0 mg/Kg S.C) and were maintained with sodium free diet. After all animals were anesthetized with 2% isoflurane in 100% O2 underwent to a cannulation of the femoral artery for mean arterial pressure and heart rate recordings. The urinary bladder was cannulated for intravesical pressure (IP) recordings. After baseline recording of the physiological parameters for 15 min, drugs (vasopressin 1 ng/mL, or acetylcholine 2 ug/mL, or noradrenaline 2 ug/mL) were administrated in situ (0.1 mL) on the urinary bladder and all the parameters were recorded for the control responses The AVP receptor subtypes were also labeled by immunofluorescence technique in the urinary bladder. Data are as mean±SE and were submitted to paired Student t‐test (p<0.001).ResultsThe water privation group responses in IP to vasopressin (39,5±1,0% vs. 110,1±1,9% control), acetylcholine (125,9±12,4% vs. 488,8±24,9% control), and noradrenaline (−17,5±1,0% vs. −67,6±1,6% control) were attenuated. Similarly the furosemide group the IP responses to vasopressin (42,8±2,8% vs. 110,1±1,9% control), acetylcholine (145,0±5,0% vs. 488,8±24,9% control), and noradrenaline (−28,8±1,0% vs. −67,6±1,6% control)were reduced. The immunofluorescence was showed a decrease in the amount of vasopressin receptors on the membrane of urinary bladder cells after dehydration in both models.ConclusionBoth models decreased the urinary bladder reactivity to vasopressin and to the neurotransmitters released by the autonomic nervous system innervation on the urinary bladder.Support or Funding InformationFinancial Support: FAPESP, CAPES and NEPAS.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
BackgroundThe effects of vasopressin on cardiac chronotropism are controversial in different species.ObjectiveTo investigate if vasopressin can influence the cardiac intrinsic activity in conscious Wistar rats.MethodsAll the procedures of this study were approved by the Animal ethics committee (protocol #02/2016). Adult male Wistar rats underwent to a cannulation of the femoral artery and vein for mean arterial pressure (MAP) and heart rate (HR) recordings and drug infusions, respectively, in conscious rats, 24 h after the surgical procedures. After baseline recordings, i.v. atropine 2 mg/kg and i.v. metoprolol 1.7 mg/kg were injected with 5 min interval. After 10 min, i.v. vasopressin 0.0625 mg/mL/5 min (N=6) or saline (1 mL/5 min) (N=6) were infused and the variables were recorded for additional 10 min. Gene and protein expression of V1a, V1b and V2 subtype receptors for AVP were also carried in the right atrium by qPCR and Western Blotting, respectively. The AVP receptor subtypes were also labeled by immunofluorescence technique in the right atrium.ResultsVasopressin evoked bradycardic (−51±5 bpm) and pressor responses (39±6 mmHg) compared to baseline post‐autonomic blockade (130 ±8 mmHg and 406±16 bpm). Saline did not change HR (1±4 bpm) and MAP (−3±1 mmHg) compared to baseline after autonomic blockade (120±5 mmHg and 411±52 bpm). All subtypes of AVP receptors were expressed in the right atrium by qPCR, Western Blotting and immunofluorescence.ConclusionThe bradycardia elicited by vasopressin after cardiac autonomic blockade suggests that vasopressin can affect the cardiac intrinsic activity binding to the receptors in the right atrium.Support or Funding InformationFinancial support: FAPESP, CNPq and NEPAS‐FMABC.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.