SummaryBackgroundFemoroacetabular impingement syndrome is an important cause of hip pain in young adults. It can be treated by arthroscopic hip surgery, including reshaping the hip, or with physiotherapist-led conservative care. We aimed to compare the clinical effectiveness of hip arthroscopy with best conservative care.MethodsUK FASHIoN is a pragmatic, multicentre, assessor-blinded randomised controlled trial, done at 23 National Health Service hospitals in the UK. We enrolled patients with femoroacetabular impingement syndrome who presented at these hospitals. Eligible patients were at least 16 years old, had hip pain with radiographic features of cam or pincer morphology but no osteoarthritis, and were believed to be likely to benefit from hip arthroscopy. Patients with bilateral femoroacetabular impingement syndrome were eligible; only the most symptomatic hip was randomly assigned to treatment and followed-up. Participants were randomly allocated (1:1) to receive hip arthroscopy or personalised hip therapy (an individualised, supervised, and progressive physiotherapist-led programme of conservative care). Randomisation was stratified by impingement type and recruiting centre and was done by research staff at each hospital, using a central telephone randomisation service. Patients and treating clinicians were not masked to treatment allocation, but researchers who collected the outcome assessments and analysed the results were masked. The primary outcome was hip-related quality of life, as measured by the patient-reported International Hip Outcome Tool (iHOT-33) 12 months after randomisation, and analysed in all eligible participants who were allocated to treatment (the intention-to-treat population). This trial is registered as an International Standard Randomised Controlled Trial, number ISRCTN64081839, and is closed to recruitment.FindingsBetween July 20, 2012, and July 15, 2016, we identified 648 eligible patients and recruited 348 participants: 171 participants were allocated to receive hip arthroscopy and 177 to receive personalised hip therapy. Three further patients were excluded from the trial after randomisation because they did not meet the eligibility criteria. Follow-up at the primary outcome assessment was 92% (319 of 348 participants). At 12 months after randomisation, mean iHOT-33 scores had improved from 39·2 (SD 20·9) to 58·8 (27·2) for participants in the hip arthroscopy group, and from 35·6 (18·2) to 49·7 (25·5) in the personalised hip therapy group. In the primary analysis, the mean difference in iHOT-33 scores, adjusted for impingement type, sex, baseline iHOT-33 score, and centre, was 6·8 (95% CI 1·7–12·0) in favour of hip arthroscopy (p=0·0093). This estimate of treatment effect exceeded the minimum clinically important difference (6·1 points). There were 147 patient-reported adverse events (in 100 [72%] of 138 patients) in the hip arthroscopy group) versus 102 events (in 88 [60%] of 146 patients) in the personalised hip therapy group, with muscle soreness being the most common of the...

The development of dicamba-tolerant and other auxin-tolerant crops will enable the use of these effective herbicides in soybean and cotton at application timings such as at planting or over-the-top that are not currently possible. This research examined the effect of various factors on detection of postapplication amounts of dicamba in the air under field conditions by coupling a sample collection system with advanced chemical analysis of those samples. The quantity of dimethylamine salt of dicamba that was detected within 48 hr after application was two times greater (P < 0.05) than the quantity of diglycoamine salt formulation based on field studies in 2009. Regardless of application timing, the amount of detected dicamba was greatest during the 0 to 12 hr time period after application. However, the total detected after 48 hr was less for evening applications (5 micrograms [µg]) compared with midday (17 µg) or morning (14 µg) applications based on 2010 field trials. Average ambient air temperature (and other weather variables) correlated with higher detection levels of dicamba in the air in the field.

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Auxins such as dicamba and 2,4-Dichlorophenoxyacetic acid (2,4-D) may volatilize when used as herbicides. In this work, a fast, straightforward method to determine the relative volatility of auxin formulations is presented. The method uses a sprayed soil substrate in a disposable closed dome system. For a 24-h period, air is drawn out of the closed dome and passed through a polyurethane foam (PUF) plug where any volatile auxin is trapped. The auxin is extracted from the PUF with methanol, and the resultant extract solution is analyzed for the auxin by liquid chromatography-mass spectrometry (either LC-MS or LC-MS\MS). The data are then used to determine the relative volatility of the formulations.