Successful pregnancy and vaginal delivery after heart transplantation

Löwenstein, Bernardo R.; Vain, Nestor W.; Perrone, Sergio V.; Wright, Daniel R.; Boullón, Fernando; Favaloro, RenéG.

doi:10.1016/0002-9378(88)90035-x

Cited by 87 publications

(24 citation statements)

References 2 publications

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“…39,43 As for timing and route of delivery, a heart-transplanted woman can theoretically undergo a vaginal delivery at term. 37,38 Cesarean section is advised when obstetric indications are present. Finally, immunosuppressed patients are usually discouraged from breastfeeding to prevent any possible risk to the infant.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy in heart transplant recipients

Miniero

Tardivo

Centofanti

et al. 2004

The Journal of Heart and Lung Transplantation

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Section: Discussionmentioning

confidence: 99%

Pregnancy in heart transplant recipients

Miniero

Tardivo

Centofanti

et al. 2004

The Journal of Heart and Lung Transplantation

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“…The first successful pregnancy after heart transplantation was reported in 1988 [10]. The Heart Transfer Review by Cowan et al [11] included 103 pregnancies in 58 recipients whereas the Lung Transfer Review by Shaner et al [12] analysed 30 pregnancies with 32 outcomes (one triplet) in 21 female lung transplant recipients.…”

Section: Heart and Lung Transplantationmentioning

confidence: 97%

The risk of obstetrical syndromes after solid organ transplantation

Brosens

Benagiano

2014

Best Practice & Research Clinical Obstetrics & Gynaecol

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“…Cyclosporine is excreted into human milk with milk-tomaternal serum concentration ratios of less than one (from 0.17 to 0.4) (2,11,12). In contrast, our results in patient 1 show that cyclosporine concentrations in milk may be higher than the corresponding maternal blood concentrations, especially after the apparent distribution phase (Fig.…”

mentioning

confidence: 99%

Cyclosporine excretion into breast milk

Moretti

Sgro²,

Johnson³

et al. 2003

Transplantation

139

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Although many female patients of childbearing age who are receiving cyclosporine have successful pregnancies, these women may be advised not to breast-feed. During recent years, cases of uneventful pregnancies and subsequent successful breast-feeding have been reported in the literature. The infant's blood cyclosporine concentration was usually very low. Based on these findings and the lack of detectable adverse effects, some investigators have suggested that women on cyclosporine may breast-feed, challenging the conventional view that cyclosporine is contraindicated during breast-feeding. Here, we report our experience with cyclosporine use during breast-feeding in five mother-infant pairs. We show a wide range of infant exposures to the drug in milk, noting that one of the infants had therapeutic blood concentrations of cyclosporine despite relatively low concentrations of the drug in milk.

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Successful pregnancy and vaginal delivery after heart transplantation

Cited by 87 publications

References 2 publications

Pregnancy in heart transplant recipients

Pregnancy in heart transplant recipients

The risk of obstetrical syndromes after solid organ transplantation

Cyclosporine excretion into breast milk

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