Industry 4.0 and Autonomous Driving are emerging resource-intensive distributed application domains that deal with open and evolving environments. These systems are subject to stringent resource, timing, and other non-functional constraints, as well as frequent reconfiguration. Thus, real-time behavior must not preclude operational flexibility. This combination is motivating ongoing efforts within the Time Sensitive Networking (TSN) standardization committee to define admission control mechanisms for Ethernet. Existing mechanisms in TSN, like those of AVB, its predecessor, follow a distributed architecture that favors scalability. Conversely, the new mechanisms envisaged for TSN (IEEE 802.1Qcc) follow a (partially) centralized architecture, favoring short reconfiguration latency. This paper shows the first quantitative comparison between distributed and centralized admission control architectures concerning reconfiguration latency. Here, we compare AVB against a dynamic real-time reconfigurable Ethernet technology with centralized management, namely HaRTES. Our experiments show a significantly lower latency using the centralized architecture. We also observe the dependence of the distributed architecture in the end nodes' performance and the benefit of having a protected channel for the admission control transactions. INDEX TERMS Ethernet, TSN, AVB, HaRTES, real-time communication, dynamic reconfiguration, admission control protocol.
Background
Bone mineral density (BMD) decreases with ART initiation with a tenofovir disoproxil fumarate-containing regimen, although bone tissue quality increases. The impact of dolutegravir (DTG)/abacavir (ABC)/lamivudine (3TC)-based ART initiation on bone health parameters is not clear.
Objectives
To study the impact of DTG/ABC/3TC-based therapy on bone health parameters in ART-naive individuals with HIV after 48 weeks of treatment.
Methods
An observational, prospective and analytical study of treatment-naive patients with HIV undergoing a DTG/ABC/3TC-based regimen at 48 week follow-up. Changes in bone strength parameters (BMD, bone microarchitecture and bone tissue quality) were assessed with non-parametric methods.
Results
Sixteen HIV-infected ART-naive patients starting DTG/ABC/3TC were included. BMD in the lumbar spine showed a significant decrease of −2.25% (P = 0.007) and −4.1% in the femoral neck (P = 0.007). Bone microarchitecture, as measured by trabecular bone score, also decreased significantly by −2.5% (P = 0.03). In contrast, bone quality [bone material strength index (BMi)], as measured by microindentation, significantly increased with respect to baseline after 48 weeks of treatment, showing better bone properties of +6.53% (P < 0.001). No significant changes were found in bone turnover markers. In addition, a positive significant correlation between the CD4/CD8 cell count ratio at baseline and changes in BMSi after 48 weeks of treatment was observed (Spearman’s rho = 0.4974; P = 0.04).
Conclusions
After a 48 week treatment with DTG/ABC/3TC-based ART, BMD and trabecular bone score decreased while bone tissue quality, as measured by microindentation, improved significantly. The state of the immune system at ART initiation is related to bone quality recovery. An overarching approach to assess bone toxicity in ART-treated patients is needed.
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