Recently, accumulating evidences indicated that microRNA-141 (miR-141) is associated with NPC due to their abilities to affect the expression of genes that modulate tumorigenesis. Unfortunately, there is still limited publication about miR-141 expression in Vietnamese nasopharyngeal cancer patients. In this study, we adopted bioinformatics tools, such as Pictar, Target Scan, miRDB, etc. to predict its target gene. As the results, PTEN (phosphatase and tensin homolog gene), acts oncogenic role associated with biological processes lead to the nasopharyngeal carcinogenesis, was identified as the direct target of miR-141. Experimentally, we reported the evaluation of miR-141 and PTEN expression in NPC biopsy samples and non-cancerous swab samples. The present study demonstrated that miR-141 was upregulated 9.38 times, and PTEN expression was significantly lowered in NPC biopsy samples compared to non-cancerous epithelial swab samples. Our finding demonstrated that the miR-141 was upregulated and PTEN was down regulated in NPC biopsy samples. In the upcoming research, a larger clinical sample size from patients at each stage of the NPC will be performed to understand the expression pattern of the miR-141 and PTEN for further applied in early diagnosis and prognosis as well as therapeutic of NPC.of new diagnosis strategies but also promising therapy. It is well known that miRNAs (micro RNAs) are short non-coding RNA molecular within about 20-23 nucleotides (nts) in length that involved in post-transcriptional regulation of multiple genes 3,4 . miRNAs are highly conserved and widely detected in animals, plants, protists and viruses, that involved in numerous cellular processes including cell proliferation, differentiation, metabolism, stress response and apoptosis 4,5 . miRNAs control cell functions by binding to sequences in 3'-untranslated region (3'-UTR) of their target mRNAs, lead to turnover
Emotion recognition or emotion prediction is a higher approach or a special case of sentiment analysis. In this task, the result is not produced in terms of either polarity: positive or negative or in the form of rating (from 1 to 5) but of a more detailed level of analysis in which the results are depicted in more expressions like sadness, enjoyment, anger, disgust, fear and surprise. Emotion recognition plays a critical role in measuring brand value of a product by recognizing specific emotions of customers' comments. In this study, we have achieved two targets. First and foremost, we built a standard Vietnamese Social Media Emotion Corpus (UIT-VSMEC) with exactly 6,927 emotionannotated sentences, contributing to emotion recognition research in Vietnamese which is a low-resource language in natural language processing (NLP). Secondly, we assessed and measured machine learning and deep neural network models on our UIT-VSMEC corpus. As a result, the CNN model achieved the highest performance with the weighted F1-score of 59.74%. Our corpus is available at our research website 1 .
Epstein-Barr Virus (EBV) infection and EBV genes' variation are considered as the etiological factors contributed to Naso-Pharyngeal Carcinoma (NPC). In the latent EBV stage, not only the latent membrane proteins but also RPMS1 expression has been confirmed in all EBV-associated tumors. In Vietnam, an Asian country with the high incidence, mortality rate of NPC, had limit research on the RMPS1 gene variation. Therefore, the objects of current study were to identify the pattern of RMPS1 variations in Vietnamese NPC patients for its value further applied in NPC patients. In this study, thirty NPC biopsy samples and thirty non-cancerous swab specimens were collected from local patients, analyzed by PCR, sequencing and compared to previous B95-8 sequence. As the results, the strongly association between the detection of RPSM1 gene and NPC incidence in Vietnamese NPC patients was determined. Additionally, the RMPS1 gene variants, including wild-type, RMPS1-B, RMPS1-C, RMPS1-C*, were identified. Among them, RMPS1-C/C* was preferential in Vietnamese nasopharyngeal cancer. In conclusion, those data is the first dataset on the polymorphism in the RPMS1 gene in Vietnamese NPC patients, and could be utilized as a promising biomarker for prognosis, diagnosis and therapy for NPC based on the EBV gene variations.in reached to 4,931 cases (ASR = 5.4/100,000) and deaths was 2,885 cases (ASR = 3.3/100,000) in Vietnamese population 3 . For the past few years, many studies have been demonstrated that the major etiological factors proposed for NPC pathogenesis, including Epstein-Barr virus (EBV) infection, genetics/or epigenetic changes and environmental factor 4-8 . In the latent EBV stage, additionally to the latent membrane proteins (LMP-1, LMP-2), and small noncoding RNAs (EBERs), as
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