These data show that apatinib treatment significantly improved OS and PFS with an acceptable safety profile in patients with advanced gastric cancer refractory to two or more lines of prior chemotherapy.
In the past half-century, surface plasmon resonance in noble metallic nanoparticles has been an important research subject. Recent advances in the synthesis, assembly, characterization, and theories of traditional and non-traditional metal nanostructures open a new pathway to the kaleidoscopic applications of plasmonics. However, accurate and precise models of plasmon resonance are still challenging, as its characteristics can be affected by multiple factors. We herein summarize the recent advances of plasmonic nanoparticles and their applications, particularly regarding the fundamentals and applications of surface plasmon resonance (SPR) in Au nanoparticles, plasmon-enhanced upconversion luminescence, and plasmonic chiral metasurfaces.
Transparent wood with high optical transmittance, excellent thermal insulation and high toughness has attracted significant attention as an energy-saving building material.
Although Rho family GTPases RhoA, RhoB and RhoC share more than 85% amino acid sequence identity, they may play distinct roles in tumor progression. RhoA and RhoC have been suggested to have positive effects on tumor progression, but the role of RhoB in cancer, particularly in gastric cancer, remains unclear. In our study, we have examined the expression levels of these three Rho GTPases in a large panel of specimens from gastric cancer patients by immunohistochemistry. We found that RhoA and RhoC expression were significantly elevated, while RhoB was reduced or absent, in surgically removed gastric cancer tissues when compared to normal gastric tissues. The significant reduction of RhoB expression was confirmed in another group of gastric cancer samples in comparison to the adjacent non-neoplastic tissues. Then we transfected the plasmids containing RhoA, RhoB or RhoC cDNA into two gastric cancer cell lines, SGC7901 and AGS cells, respectively. By overexpression experiments, we found that RhoA promoted the gastric cancer cell proliferation and RhoC stimulated migration and invasion of the cancer cell. RhoB expression, however, significantly inhibited the proliferation, migration and invasion of the gastric cancer cells and also enhanced the chemosensitivity of these cells to anticancer drugs. It appears that RhoB plays an opposing role from that of RhoA and/or RhoC in gastric cancer cells. Our work suggests that RhoB may play a tumor suppressor role and subsequently may have potential implications in future targeted therapy.
We demonstrate a significant right-handed circularly polarized luminescence of CdSe/CdS quantum rods by doping them into a self-assembled left-handed helical structure of cellulose nanocrystals.
Perovskites have attracted substantial attention on account of their excellent physical properties and simple preparation process. Here we demonstrated an improved photodetector based on solution-processing organic-inorganic hybrid perovskite CH
3
NH
3
PbI
3−
x
Cl
x
layer decorated with CsPbBr
3
perovskite quantum dots. The CH
3
NH
3
PbI
3−
x
Cl
x
-CsPbBr
3
photodetector was operated in a visible light region, which appeared high responsivity (
R
= 0.39 A/W), detectivity (
D*
= 5.43 × 10
9
Jones), carrier mobility (
μ
p
= 172 cm
2
V
−1
s
−1
and
μ
n
= 216 cm
2
V
−1
s
−1
), and fast response (rise time 121 μs and fall time 107 μs). The CH
3
NH
3
PbI
3−
x
Cl
x
-CsPbBr
3
heterostructure is anticipated to find comprehensive applications in future high-performance photoelectronic devices.
Electronic supplementary material
The online version of this article (10.1186/s11671-019-3082-z) contains supplementary material, which is available to authorized users.
For a series of phospholipid coated calamitic nematic liquid crystal droplets (5CB, 6CB, 7CB, E7 and MLC7023) of diameter ~18m, the addition of chiral dopant leaves the sign of surface...
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