There are numerous studies researching ways to alleviate injection pain for propofol. The most frequently used agent for this purpose has been lidocaine that is used before or with propofol [13][14][15]. There are also studies on the use of hypnotic agents (thiopental sodium, ketamine etc), opiates (alfentanil, sufentanil, remifentanil), dexmedetomidine, magnesium, nonsteroidal analgesic medication, antiemetics and physical applications such as cold packs to alleviate injection pain [13,14,[16][17][18][19][20][21].
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