Irritant contact dermatitis (ICD) is an inflammatory epidermal disorder associated with physical or immunological provocation that results in impaired skin barrier. The prevalence of ICD is found to be 17-30% in healthcare workers compared to general population. The first-line management strategies of ICD is based on prevention. Intensive hand cleansing is one of the causes of ICD. Hand hygiene is general term that refers to any action of hand cleansing. Hand hygiene practices include hand washing and hand rubbing with antiseptics. Hand hygiene is the most effective preventive measure in preventing infection control, especially in the era of coronavirus (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since December 2019. This disease is transmitted through inhalation or contact with infected droplets. Prevention and mitigation actions are key in controlling infection.
The most frequently reported complaints in the urogenital organ system is leukorrhea, also known as fluor albus. Leukorrhea is a discharge secreted from the genital organs, mostly occur in female. Leukorrhea has a significant incidence rate and varies according to many factors such as hormone and infection. Leukorrhea can be physiological in female, but when excess discharge is accompanied by other characteristics, the leukorrhea is considered pathological. This genital discharge also occurs in male for pathological reasons, mainly caused by infection. Several pathogenic infections, whether transmitted through secual contact or not, are the etiology of complaints of leukorrhea. Some specific pathogens will cause different symptoms in the two sex groups. To make a diagnosis, it is important for the examiner to carry out a detailed and coherent history, especially regarding sexual contact and a history of risky sexual behavior. Although some infections are asymptomatic, complications may occur if infections are not treated properly as early as possible. The management of leukorrhea is based on an examination and treatment algorithm with syndromic approach.
Background: Male androgenetic alopecia (MAGA), also known as androgenetic alopecia, is the most common hair loss in males who have a genetic predisposition. The pattern of baldness in MAGA starts from the frontal area in a triangular pattern, followed by progressive thinning of the vertex until baldness occurs. Generally, the diagnosis of MAGA is established by clinical examination. FDA has approved a combination of topical minoxidil and oral finasteride for MAGA treatment. Currently, there is another treatment option like dutasteride, a prostaglandin analog, ketoconazole, and co-adjuvant therapy like laser therapy, hair transplantation, and so on. Purpose: To provide an updated treatment for MAGA. Review: Etiopathogenesis of MAGA is influenced by genetic susceptibility and hormonal factors. The European Consensus Group set the evaluation diagnosis of MAGA to include a historyof hair fall, physical examination, hair examination, supporting examination, and clinical documentation. There are therapeutic options for MAGA, including antiandrogen therapies, androgen-independent therapies, and co-adjuvant therapies. The FDA has approved a combination of topical minoxidil and oral finasteride for MAGA treatment. MAGA may affect patients’ quality of life and self-esteem. In general, patients expect higher. Conclusion: MAGA is the most common progressive hair loss in males. The MAGA therapy is expected to achieve cosmetically significant regrowth and to slow additional hair loss.
Introduction: Linear IgA dermatosis is a rare autoimmune vesiculobullous disease characterized by homogeneous linear IgA deposits in basement membrane of epidermis, and it can be idiopathic or drug-induced. The pathogenesis of drug-induced linear IgA dermatosis is not fully known yet, but it is associated with specific T cells. The clinical manifestations of the disease include vesiculobullous eruption, erythematous plaques, or string of pearls. Most cases still need additional therapy to avoid the expansion of the disease. Case Presentation: In this study, we present a 17-year-old male patient with erythema plaques, vesicles, and bullae with erosion in facial, oral, neck, trunk, genital, and extremities, pruritus, and burning sensation. The patient was undergoing pulmonary tuberculosis (TB) treatment for one week. Physical examination was done, and total BSA 10% and negative Asboe-Hansen sign were seen. The treatment consisted of delaying administration of TB drugs, desoximetasone cream 0.25%, cetirizine 10 mg, and aspiration of bullae. Conclusions: Drug-induced linear IgA dermatosis can occur at any age due to the administration of rifampicin and other antibiotics, angiotensin-I converting enzyme (ACE) inhibitors, or nonsteroidal anti-inflammatory drugs (NSAIDs). The drug can stimulate specific T cells that release Th2 cytokines to produce IgA antibodies against the basement membrane of epidermis. Drugs may cause an autoimmune response by cross-reaction with the target epitope, altering the conformation of epitopes, or exposing previously sequestered antigens to the immune system. The causative drug was stopped, and methyl prednisolone 0.5 - 1 mg/kg/day was given as initial therapy. In this study, we reported a rare case of a 17-year-old male with anti-TB drug-induced linear IgA dermatosis. Diagnosis was done based on clinical manifestation, histopathology, and immunofluorescence. The causative drug was stopped, the patient was given topical and systemic steroid therapy and drug desensitization. Remission was noted after six weeks of therapy, and oral steroid was slowly tapered and stopped on day 42. After stopping oral steroids, no lesions were reported. A 6-month follow-up revealed no signs of recurrence.
The most frequently reported complaints in the urogenital organ system is leukorrhea, also known as fluor albus. Leukorrhea is a discharge secreted from the genital organs, mostly occur in female. Leukorrhea has a significant incidence rate and varies according to many factors such as hormone and infection. Leukorrhea can be physiological in female, but when excess discharge is accompanied by other characteristics, the leukorrhea is considered pathological. This genital discharge also occurs in male for pathological reasons, mainly caused by infection. Several pathogenic infections, whether transmitted through secual contact or not, are the etiology of complaints of leukorrhea. Some specific pathogens will cause different symptoms in the two sex groups. To make a diagnosis, it is important for the examiner to carry out a detailed and coherent history, especially regarding sexual contact and a history of risky sexual behavior. Although some infections are asymptomatic, complications may occur if infections are not treated properly as early as possible. The management of leukorrhea is based on an examination and treatment algorithm with syndromic approach.
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