This study aimed to analyze the acute effect of anodal transcranial direct current stimulation (a-tDCS) over the primary motor cortex (M1) on the volume, perceived exertion, and neuromuscular performance measurements in trained and untrained adults. Twenty-four male adults (12 trained and 12 untrained) participated in this single-blind, randomized, and sham-controlled study. The participants performed three back squat repetitions using the 15RM load with maximal concentric velocity to assess neuromuscular performance before tDCS and 30-min after resistance exercise. Next, they were randomly assigned to a-tDCS over M1 or the sham condition. Participants performed ten sets of parallel back squat with 15RM load and repetitions sustained to momentary muscular failure. The total number of repetitions was higher (p<0.05) and perceived exertion was lower (p<0.05) after a-tDCS in both groups. Peak power, velocity, and force decreased in both groups after the RE session (p<0.05), but with a higher rate in untrained individuals (p<0.05). No significant effect was found for peak power, peak velocity, and peak force (p>0.05). This study suggests that using a-tDCS may improve the total volume of repetitions and perceived exertion in trained and untrained individuals.

The assessment of parasympathetic nervous activity and psychophysiological responses infers the stress imposed by different resistance training systems. Therefore, we compare the effects of different sets configurations, with similar volume (~60 repetitions), on heart rate variability indices and internal training load. Twenty-nine resistance-trained adults completed the following conditions: traditional without and with muscle failure, inter-repetition rest, and rest-pause in the parallel squat. The heart rate variability indices (time-domain) were measured before and 30 min after each condition. The internal training load was obtained through the session-rating of perceived exertion method. Except for inter-repetition rest, all conditions reduced the heart rate variability indices after the session (P<0.05), and the rest-pause triggered the higher reductions (≤−46.7%). The internal training load was higher in the rest-pause (≤68.9%). Our results suggest that rest-pause configuration leads to more considerable disruption of the parasympathetic nervous activity and higher internal training load in trained adults. In contrast, inter-repetition rest allows lower autonomic and psychophysiological stress.