Background Data comparing outcomes in heart failure ( HF ) across Asia are limited. We examined regional variation in mortality among patients with HF enrolled in the ASIAN ‐HF (Asian Sudden Cardiac Death in Heart Failure) registry with separate analyses for those with reduced ejection fraction ( EF ; <40%) versus preserved EF (≥50%). Methods and Results The ASIAN ‐ HF registry is a prospective longitudinal study. Participants with symptomatic HF were recruited from 46 secondary care centers in 3 Asian regions: South Asia (India), Southeast Asia (Thailand, Malaysia, Philippines, Indonesia, Singapore), and Northeast Asia (South Korea, Japan, Taiwan, Hong Kong, China). Overall, 6480 patients aged >18 years with symptomatic HF were recruited (mean age: 61.6±13.3 years; 27% women; 81% with HF and reduced r EF ). The primary outcome was 1‐year all‐cause mortality. Striking regional variations in baseline characteristics and outcomes were observed. Regardless of HF type, Southeast Asians had the highest burden of comorbidities, particularly diabetes mellitus and chronic kidney disease, despite being younger than Northeast Asian participants. One‐year, crude, all‐cause mortality for the whole population was 9.6%, higher in patients with HF and reduced EF (10.6%) than in those with HF and preserved EF (5.4%). One‐year, all‐cause mortality was significantly higher in Southeast Asian patients (13.0%), compared with South Asian (7.5%) and Northeast Asian patients (7.4%; P <0.001). Well‐known predictors of death accounted for only 44.2% of the variation in risk of mortality. Conclusions This first multinational prospective study shows that the outcomes in Asian patients with both HF and reduced or preserved EF are poor overall and worst in Southeast Asian patients. Region‐specific risk factors and gaps in guideline‐directed therapy should be addressed to potentially improve outcomes. Clinical Trial Registration URL : https://www.clinicaltrials.gov/ . Unique identifier: NCT 01633398.

Aim:Yucca schidigera extract has been successfully used as feed additives in the poultry industry. It enhances the growth and productivity in broiler production. Hence, the present study was designed to analyze the effect of Y. schidigera extract in growth, carcass quality and behavior along with its economical utility in broiler rearing.Materials and Methods:Total, 120 numbers of day-old broiler chicks of equal sex ratio were randomly divided into Yucca supplemented treatment and control group, each having 60 birds in three replications of 20 numbers. The feeding management and rearing conditions were similar for all the groups as per the standard except the Yucca supplementation in the treatment group @ 125 mg/kg of feed. The parameters with respect to growth, carcass, behavior, and litter content were recorded as per standard procedures.Results:The Yucca supplementation can effectively enhance growth of 173 g in 6th week by utilizing lesser feed intake than control group, which ultimately proves better feed conversion rate, protein efficiency ratio, and energy efficiency ratio in broiler production. Eviscerated weight of 58.50% for the treatment group was significantly higher (p<0.05) than 54.10% in the control group. The breast meat yield of Yucca group (32.23%) was significantly higher (p<0.05) than control (30.33%). More frequency of agonistic behavioral expressions was noticed in the control group than the treatment group. A profit of 43.68% was received by usage of Yucca supplementation in the diet on live weight basis. Numerically, lower percentage of moisture was present in Yucca treated group than the control.Conclusion:From this study, it can be concluded that Yucca supplementation has an important role in augmenting broiler‘s growth performance, efficiency to utilize feed, protein and energy, and survivability. Hence, use of Yucca powder in broiler ration could be beneficial to maintain the litter quality, which directly enhances the productivity in broiler production without any adverse effect.

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A 42-day study was conducted to evaluate the effect of ground full-fat flaxseed supplementation on growth performance, carcass characteristics, α-linolenic acid (ALA), linoleic acid (LA) and organoleptic characteristics of broiler meat. A total of 200 one-day-old broiler chicks were randomly allocated to five experimental groups and were fed isoenergetic and isonitrogenous diets containing flaxseed at 0%, 2.5%, 5.0%, 7.5% and 10%. Flaxseed supplementation did not affect the weekly body weight of broiler chicks during the first three weeks, but thereafter it reduced significantly with increasing levels of flaxseed in the diets. Birds fed on 10% flaxseed showed a reduction of 10.08% in body weight as compared to the control group. Diets containing 5.0-7.5% flaxseed resulted in significantly lower weight gain, higher feed conversion ratio, energy efficiency ratio and lower protein efficiency ratio as compared to control and 2.5% flaxseed diets. The carcass characteristics data indicated a little variation in the evisceration rate and giblet among treatment groups, but the breast yield was significantly higher in control than flaxseed groups. The protein, fat and ash content of broiler meat were not affected with the level of flaxseed in the diets. However, the inclusion of flaxseed in the diets significantly increased the ALA in the breast and thigh tissues with no difference in the organoleptic quality of meat.