Au nanoparticles (NPs) have been found to be excellent glucose oxidase mimics, while the catalytic processes have rarely been studied. Here, we reveal that the process of glucose oxidation catalyzed by Au NPs is as the same as that of natural glucose oxidase, namely, a two-step reaction including the dehydrogenation of glucose and the subsequent reduction of O2 to H2O2 by two electrons. Pt, Pd, Ru, Rh, and Ir NPs can also catalyze the dehydrogenation of glucose, except that O2 is preferably reduced to H2O. By the electron transfer feature of noble metal NPs, we overcame the limitation that H2O2 must be produced in the traditional two-step glucose assay and realize the rapid colorimetric detections of glucose. Inspired by the electron transport pathway in the catalytic process of natural enzymes, noble metal NPs have also been found to mimic various enzymatic electron transfer reactions including cytochrome c, coenzymes as well as nitrobenzene reductions.
Chronic wound is a common complication
for diabetic patients,
which
entails substantial inconvenience, persistent pain, and significant
economic burden to patients. However, current clinical treatments
for diabetic chronic wounds remain unsatisfactory. A prolonged but
ineffective inflammation phase in chronic wounds is the primary difference
between diabetic chronic wounds and normal wounds. Herein, we present
an effective antioxidative system (MOF/Gel) for chronic wound healing
of diabetic rats through integrating a metal organic framework (MOF)
nanozyme with antioxidant enzyme-like activity with a hydrogel (Gel).
MOF/Gel can continuously scavenge reactive oxygen species to modulate
the oxidative stress microenvironment in diabetic chronic wounds,
which leads to a natural transition from the inflammation phase to
the proliferation phase. Impressively, the efficacy of one-time-applied
MOF/Gel was comparable to that of the human epidermal growth factor
Gel, a widely used clinical drug for various wound treatments. Such
an effective, safe, and convenient MOF/Gel system can meet complex
clinical demands.
Proposing a simple strategy for developing
full-color carbon quantum
dots (CQDs) and exploring how the luminescence can be tuned and improved
is attractive and encouraging. Herein, blue, green, yellow-green,
and orange-red CQDs doped with heteroatoms were synthesized in one
pot and separated by column chromatography, with emission peaks of
435 nm, 495 nm [photoluminescence quantum yield (PLQY) of 88.9%],
525 nm, and 595 nm (full width at half-maximum of 31 nm), respectively.
The abundant C–O/C–O–C electron donor groups
greatly improve the PLQY of green CQDs, and the expended effective
conjugated domains (particle size, doped chlorine, and conjugated
nitrogen) of CQDs boost the red-shifts of emission spectra. Energy
transfer (ET) in a concentrated mixed solution of CQDs was discovered,
and possible ET mechanisms are proposed. Furthermore, a high-efficiency
white light-emitting diode with Commission Internationale de L’Eclairage
coordinates of (0.361, 0.369), a correlated color temperature of 4534
K, and a high color rendering index of 90.8 was fabricated.
Mechanism research of nanozymes has always been of great interest since their emergence as outstanding mimics of friable natural enzymes. An important but rarely mentioned issue in mechanism research of...
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