10 monkeys (macaques) received adriamycin by monthly intravenous injections at 12 mg/m2 (1 mg/kg). 8 of the 10 monkeys developed congestive heart failure at an average cumulative adriamycin dose (310 mg/m2) well below that considered the safe upper limit (550 mg/ m2) in man. Histologically, the myocardial lesions resembled those found in human anthracycline-induced cardiomyopathy. 1 of the 10 monkeys developed acute myeloblastic leukemia after receiving 324 mg/m2 of adriamycin; the 10th monkey is alive and well 26 months after the last dose of drug. Our results suggest that adriamycin is a more potent cardiotoxin in monkeys than in man, and that leukemia may be a consequence of prolonged treatment with this drug.
Radiofrequency ablation (RFA) for atrial fibrillation (AF) has emerged as an effective and reliable treatment modality. Since its introduction in the 1990s, major and minor complications have been identified. Major complications include periprocedural death, atrioesophageal (AE) fistula, stroke, cardiac perforation and tamponade, pulmonary venous stenosis, phrenic nerve injury, retroperitoneal hematoma, and arrhythmias. Minor complications include pseudoaneurysms and arteriovenous fistulas. We report an extremely rare and life-threatening complication of bronchopericardial fistula following AF ablation resulting in respiratory complications.
Business and Economic Research (BER) would like to thank the following reviewers for reviewing manuscripts from September 1, 2022, to January 1, 2023. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Many authors, regardless of whether BER publishes their work, appreciate the helpful feedback provided by the reviewers. Macrothink Publishing appreciates the following reviewers’ rigorous and conscientious efforts for this journal. Each of the reviewers listed below returned at least one review during this period.Abeer M. Ali Abd ElkhalekAhmed ZouhairAlmir A. AlihodžićAngela WrightBratu (Simionescu) MihaelaCosimo MagazzinoCristina Alina NaftanailaElena GurguFayez Bassam ShriedehHengky Sumisto HalimJosé MartinsKimty SengMamta SinghMohsen MohagheghMuddassar SarfrazNemer BadwanOleksandr V. DluhopolskyiRoderikus Agus TrihatmokoRomeo Victor IonescuSantosh B. ManjegowdaShyamkumar D. KalpandeYixun XingZi-Yi Guo
Business and Economic Research (BER) would like to thank the following reviewers for reviewing manuscripts from March 1, 2023, to June 1, 2023. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Many authors, regardless of whether BER publishes their work, appreciate the helpful feedback provided by the reviewers. Macrothink Publishing appreciates the following reviewers’ rigorous and conscientious efforts for this journal. Each of the reviewers listed below returned at least one review during this period. Cristina Alina NaftanailaEddie John FisherFayez Bassam ShriedehGita SugiyartiHengky Sumisto HalimHui Shan LeeJosé MartinsMohsen MohagheghNaftaly MoseNana Osei-BonsuNemer BadwanRoderikus Agus TrihatmokoSaid Sayed AbdoSantosh B. Manjegowda
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