Continuous productionof D-fi -hydroxyisobutyric acid (D-HIBA) from methacrylic acid (MA) using Candida rugosa IF0 0750 was most efficient under ammonium-limited conditions, whereas D-HIBA was not detected under glucose-limited conditions. As high as 21.5 g D-HIBA/Z with 55% molar conversion yield from MA was obtained at a dilution rate of 0.04 h-l.
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