Question: Does remote ischemic conditioning improve neurological function in patients with acute moderate ischemic stroke? Findings: In this randomized clinical trial that included 1893 participants with acute moderate ischemic stroke, excellent neurological function at 90 days in those randomized to remote ischemic conditioning compared with usual care occurred in 67.4% vs 62.0%, a difference that was statistically significant.Meaning: Although remote ischemic conditioning was associated with better neurological function in patients with acute moderate ischemic stroke, this trial requires replication before concluding efficacy for this intervention.
The results suggest that the proposed wearable actigraphy system is practical for the in-home screening of objective sleep measurements and objective evaluation of sleep improvement after treatment.
Ascorbic acid (AA) was encapsulated in glassy low-dextrose equivalent maltodextrin matrix by extrusion. The effects of formulation parameters, i.e., core ⁄ matrix ratio and water content were mainly investigated on T g of extrudate. The AA yield, AA content and water content of the products together with extrusion parameters were also determined and compared for different formulations. The T g of extrudates containing water content from 7.860% to 10.430% ranged from 43.17 to 27.48°C, and the T g of extrudates which core to matrix from 1:4 to 1:8 ranged from 35.79 to 41.64°C. AA yield of all extrudates is above 96%, and with increasing water content, there was a slight decrease in the AA yield. The increased water level and core ⁄ matrix ratio reduce specific mechanical energy and die head pressure. X-ray diffraction and scanning electron microscopy suggested that AA was most likely molecularly dispersed within the maltodextrin indicating the miscibility of AA and maltodextrin.
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