A Portable Wireless Online Closed-Loop Seizure Controller in Freely Moving Rats

Young, Chung-Ping; Liang, Sheng-Fu; Chang, Da-Wei; Liao, Yicheng; Shaw, Fu-Zen; Hsieh, Chao-Hsien

doi:10.1109/tim.2010.2050358

Cited by 60 publications

(24 citation statements)

References 20 publications

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“…The number of recording channels required in a study depends on the problem to be investigated. For example, online detection of absence seizure can be achieved by using a single EEG channel [32], [33]. However, all of the seven recording channels were used when monitoring a fully kindled TLE in this paper.…”

Section: Discussionmentioning

confidence: 99%

A Versatile Wireless Portable Monitoring System for Brain–Behavior Approaches

Chang

Liang

Young

et al. 2011

IEEE J. Emerg. Sel. Topics Circuits Syst.

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It is critical to set up a precise and feasible monitoring system for a variety of animal and human studies. A multichannel wireless system for monitoring physiological signals of freely moving rats is presented. This system combines electroencephalogram (EEG) and acceleration signals, enabling the study of association between brain and behavior. A combination of EEG and accelerometers eliminates the necessity for complicated video installation as well as time-consuming and tedious analysis of recorded videos. The IEEE 802.15.4 based wireless communication frees the experimental subject from the hassle of wires and reduces wire artifacts during recording. Long-period continuous recording was possible because of the low power feature of the system. Methods for automatic wake-sleep state discrimination and temporal lobe epileptic seizure detection are also proposed to demonstrate the advantages of the system. An accuracy of up to 96.22% for the automatic discrimination of wake-sleep states is an advantage of our system. In addition, the detection of amygdala-kindling temporal lobe seizures reaches 100% with zero false alarms, greatly saving manpower in the identification of temporal lobe epilepsy.

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Section: Discussionmentioning

confidence: 99%

A Versatile Wireless Portable Monitoring System for Brain–Behavior Approaches

Chang

Liang

Young

et al. 2011

IEEE J. Emerg. Sel. Topics Circuits Syst.

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“…BCIs can allow patients who have movement disorders to control external devices directly through neural signals from a brain. Deep brain stimulation (DBS) is a related technology that can be used to treat neurological disorders such as Parkinson's disease [11][12][13], depression [14], and epilepsy [15,16]. An open-loop DBS system is relatively easy to configure, and is a preferred approach when patients have to undergo repeated surgery.…”

Section: Introductionmentioning

confidence: 99%

“…A closed-loop DBS system [16][17][18] monitors brain activities and delivers a modified stimulation. There are three main advantages of a closed-loop DBS: 1) it provides stimulation tailored to each patient; 2) extends the period between surgeries; 3) produces the minimum current necessary to reduce symptoms and therefore reduces the side effects that can result from an overstimulation.…”

Section: Introductionmentioning

confidence: 99%

A 4×32-Channel Neural Recording System for Deep Brain Stimulation Systems

Kim

Yang

et al. 2017

JSTS:Journal of Semiconductor Technology and Science

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“…Swivels are sometimes used to solve the dragging, but the price can be another problem, the channel numbers are limited and the implanted laboratory animal still cannot behave in their nature condition because the wires. Benefit to the rapid developments of wireless communication, many different kind of wireless solution, including Zigbee [1] and Bluetooth [2], have been commercialized and applied in animal studies. Batteries are common used to eliminate the problem of power wires.…”

Section: Introductionmentioning

confidence: 99%