Background-Allograft rejection continues to be a vexing problem in clinical lung transplantation, and the role played by passenger leukocytes in the rejection or acceptance of an organ is unclear. Here we tested whether recipient-matching of donor graft passenger leukocytes would impact graft survival in a preclinical model of orthotopic left lung transplantation.
Introduction: Cytotoxic T lymphocyte (CTL) recognition of allogeneic MHC1-complexed epitopes is a defining mechanism of acute allograft rejection. Lifelong systemic immunosuppression achieves allograft tolerance through global CTL reduction, but carries significant morbidity. As an alternate route to tolerance, we propose to impair the CTL response via removal of MHC1 within the allograft vasculature. Using an ex vivo approach, we examined the impact of "tolerizing" the allograft endothelium through MHC1-knockdown in an established CTA model.
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