The absolute configuration of elemol has been proved to be as shown in formula (V) by a synthesis of eleman-2,3,1 l-trio1 (XXXIII) from (+)-epia-cyperone (XI), a sesquiterpene of known absolute configuration.ELEMOL is a crystalline, unsaturated, tertiary-alcoholic sesquiterpene which has structure An indication of its relative stereochemistry is given by the formation of the lactone (111) from dihydroelemol (11), while the isolation of eudesmane (IV) on hydrogenation of the mixed hydrocarbons obtained by pyrolysis of elemyl benzoate or p-nitrobenzoate suggests, but does not prove, that the absolute configuration is as in structure (V). This has now No decisive proof of its absolute configuration has been published. * Part VII, J . , 1961, 4211.
I consider then that to render a reason of an effect orphaenomenon, is to deduce it from something else in nature more known than itselfl. and that consequently there may be divers kinds of degrees of explication of the same thing. For although such explications be the most satisfactory to the understanding wherein it is shewn how the efect is produced by the more primitive and catholick affections of matter, namely, bulk, shape and motion; yet are not those explications to be despised, wherein particular effects are deduced from more obvious and familiar qualities or states of bodies. For . . . . every new measure of discovery doth instruct andgratify the understanding.R. Boyle, 'Certain Physiological Essays', 1772.Precision is not to be sought for alike in all discussions . . . . It is the mark of an educated man to look for precision in each class of things just so far as the nature of the subject admits. Aristotle, 'Nichomachaean Ethics'.
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