Summary Helminth parasites and pathomorphological lesions in the organs of 56 cats from 7 villages in Bulgaria with human endemic nephropathy and 10 cats from 1 non‐endemic village were studied. The following 7 helminth species were found: Taenia crassiceps in 1, Hydatigera taeniaeformis in 50, Dipylidium caninum in 3, Joyeuxiella pasqualei in 3, Ancylostoma tubaeforme in 7, Toxocara cati in 60 and Aelurostrongylus abstrusus in 22 cats. Only 4 of 66 cats were free of parasites. Antibodies against 7 serotypes of leptospira and Toxoplasma gondii were found in 24 and 6 cats, respectively. Pathomorphological lesions characteristic for visceral larva migrans and/or larvae themselves were observed in the lungs, liver, kidneys and urinary bladder. None of the features were specific for cats originating from villages where human nephropathy was endemic. Zusammenfassung Helminthen und pathomorphologische Läsionen bei Katzen aus bulgarischen Dörfern mit humaner endemischer Nephropathie Die Organe von 56 Katzen aus 7 bulgarischen Dörfern mit humaner endemischer Nephropathie und von 10 Katzen eines nicht‐endemischen Dorfes wurden auf Helminthen und pathomorphologische Läsionen untersucht. Die folgenden 7 Spezies wurden nachgewiesen: Taenia crassiceps bei einer Katze, Hydatigera taeniaeformis bei 50, Dipylidium caninum bei 3, Joyeuxiella pasqualei bei 3, Ancylostoma tubaeforme bei 7, Toxocara cati bei 60 und Aelurostrongylus abstrusus bei 22 Katzen. Es waren nur 4 von 66 Katzen parasiten‐frei. Antikörper gegen 7 Serotypen von Leptospiras wurden bei 24 und Toxoplasma gondii bei 6 Katzen festgestellt. Pathomorphologische Läsionen die für die viscerale larva migrans und/oder für die Larven selbst characteristisch sind wurden in den Lungen, Leber, Nieren, Harnblase der untersuchten Katzen beobachtet. Keines der Merkmale war für die Katzen spezifisch, die aus den Dörfern stammten, wo die humane Nephropathie endemisch war. Résumé Hélminthes et lésions pathomorphologiques chez des chats provenant de villages bulgares avec des habitats atteints de nephropathie endémique On a recherché des hélminthes et des lésions pathomorphologiques dans les organes de 56 chats provenant de 7 villages bulgares avec des habitants atteints de néphropathie endémique et chez 10 chats d'un village non atteint. Les 7 espèces suivantes ont été mises en évidence: Taenia crassiceps chez 1 chat, Hydatigena taeniaeformis chez 50, Dipylidium caninum chez 3, Joyeuxiella pasqualei chez 3, Ancylostoma tubaeforme chez 7, Toxocara cati chez 60 et Aelurostrongylus abstrusus chez 22 chats. 4 chats sur 66 seulement n'étaient pas parasités. On a mis en évidence des anticorps contre 7 sérotypes leptospires chez 24 chats et contre Toxoplasma gondii chez 6 chats. Des lésions pathomorphologiques ont été observées dans les poumons, le foie, les reins et la vessie des chats examinés pour Larva migrans viscérale et/ou caractéristiques de ces mêmes larves. Aucune observation ne fut spécifique pour les chats qui provenaient des villages dont des habitants souffraient de néphropa...
This paper describes experiments in vitro to investigate the interaction between isolated protoscoleces from Echinococcus granulosus and E. multilocularis and human endothelial cells in monolayer culture. During a maximum coculture period of 48 h neither protoscoleces nor endothelial cells showed evidence of cytotoxicity. However, protoscoleces adherent to either endothelial cells or artificial substrata developed a glycocalyx-like coat. Adherence of protoscoleces to endothelial cells requires serum (pooled human serum or foetal calf serum) in a dose-dependent fashion. However, protoscolex adhesion to artificial substrates such as glass with or without gelatin coating was markedly inhibited by serum. Thus, even 0.001% serum reduced adhesion by 46% compared with the control value. Whilst the chemical nature of the serum components have not been identified, these experiments show that serum contains both inhibitory and promoting factors for protoscolex adhesion, a finding of possible significance for the therapeutic prevention of systemic spread of established Echinococcus infections.
Zusammenfassung Es wurden 11 streunende Katzen auf Befall rnit Echinococcus multilocularis unter‐sucht. Bei 5 Katzen wurden Stadien dieses Parasiten mit reifen Endgliedern gefunden. Summary Finding of Echinococcus multilocularis in stray domestic cats in South Germany Eleven stray cats were examined for the presence of E. multilocularis and five of them showed parasites (25—500 per cat) with ripe segments.
Bangham-type liposomes, undergoing freeze-thawing cycles, were detected electron microscopically in the brain, liver and spleen of experimental animals 24 h after rectal administration. This novel approach has several important advantages over intravenous, intraperitoneal and other usual means of administration of liposome drug-entrapped treatment and diagnostics for human application. The location of the liposomes in the brain after rectal administration shows that the brain-blood barrier can be overcome successfully by this method. Moreover, the risk of embolism and hypersensitivity, strict control of sterility and some other undesirable effects can be avoided. The possible role of rectal administration in the development of liposome drug-entrapped treatment and diagnostics is discussed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.