Brain, liver and spleen detection of liposomes after rectal administration

Abstract

Bangham-type liposomes, undergoing freeze-thawing cycles, were detected electron microscopically in the brain, liver and spleen of experimental animals 24 h after rectal administration. This novel approach has several important advantages over intravenous, intraperitoneal and other usual means of administration of liposome drug-entrapped treatment and diagnostics for human application. The location of the liposomes in the brain after rectal administration shows that the brain-blood barrier can be overcome successfully by this method. Moreover, the risk of embolism and hypersensitivity, strict control of sterility and some other undesirable effects can be avoided. The possible role of rectal administration in the development of liposome drug-entrapped treatment and diagnostics is discussed.

Advancements in Rectal Drug Delivery Systems: Clinical Trials, and Patents Perspective

“…The position of the liposomes in the brain following rectal administration demonstrates that this procedure can effectively cross the brain-blood barrier. Furthermore, the chance of embolism and hypersensitivity, as well as tight sterility regulation and a variety of other adverse effects, can be avoided [ 92 ]. Rectal administration can play a vital role in producing liposome drug-entrapped treatment and diagnostics.…”

Advanced Delivery Systems for Peptides and Proteins — Pharmaceutical Considerations

“…Rarely do peptides and proteins have structures that would be recognised by some natural active transport processes and even if materials are taken up into cells intact there is the very likely possibility that the macromolecule will undergo storage or metabolism within the cell without being transferred to the systemic circulation (Gabev andFoster, 1983 ~ Lecce, 1984).…”