Two simple, sensitive and accurate spectrophotometric methods have been developed for the estimation of Acebrophylline in bulk and in pharmaceutical formulations (Method A & Method B). Method A is based on the formation of orange red colored chromgen with ferric chloride in the presence of 2,22 -bipyridyl which obeys beer's law in the concentration range of 10-100 µg/ml exhibiting maximum absorption at 522nm. Method B is based on the diazotization of Acebrophylline with nitrous acid. The diazonium salt formed was then coupled with â-naphthol which shows maximum absorption at 456nm (yellow colored chromogen). It obeys Beer's law in the concentration ranging from 50-300 µg/ml. The methods were extended to capsule formulation and there was no interference from excipients and diluents. These methods have been statistically validated and are found to be precise and accurate.
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