The plasma histamine levels were reported to increase in early hours of the morning in asthmatic patients. It was supposed that this phenomenon would also be observed in normal volunteers. In this study using twelve normal healthy volunteers the plasma histamine levels were examined in a pharmacokinetic manner. It could be shown that plasma histamine levels flow biorhythmic changes with 3 maxima and 3 minima. The acrophases of the maxima are 12.77 +/- 0.61, 19.33 +/- 0.78 and 5.42 +/- 1.83 h. The most important rise in plasma histamine levels was found in the early hours of the morning representing about 55% of the total histamine available in plasma.
Die Peptid‐Synthese durch Vier‐Komponenten‐Kondensation läßt sich jetzt so gestalten, daß praktisch isomerenfreie Produkte entstehen. Der Trick besteht in der Verwendung eines asymmetrisch induzierenden Reagens (das zurückgewonnen wird) und in einer exponentiellen Selektivitätsverstärkung durch selektive Acidolyse des zunächst gebildeten Diastereomerengemisches.magnified image
The aim of the study was to develop a laboratory system to challenge mite allergic patients with physiological concentrations of Der p I in order to evaluate the efficacy of antiallergic drugs in mite allergic patients. A double-blind, placebo-controlled, cross-over study was designed with three consecutive sessions. Twelve patients with proven sensitivity to dust mite were treated with a single dose of dimethindene maleate in a FOAD formulation (4 and 8 mg vs. placebo) 12 h before a long-term challenge with mite allergen Der p I in the Vienna challenge chamber. Challenge was performed with a constant concentration of 40 ng Der p I per cubic meter of air for 4 h. Nasal parameters were recorded at 15 min intervals during long-term challenge. In comparison to placebo, dimethindene leads to a statistically significant reduction (p < 0.05) of the nasal response at both concentrations tested. The house-dust mite model in the Vienna challenge chamber thus proved to be a useful tool for drug investigations in mite allergies.
the study of this kind of ring-chain tautomerism than other conventional methodsf2]. Thus, compounds ( 3 a ) , X = C 0 2 C 2 H 5 and (3 a ) , X = CO,-tert-B~[~l were found to occur in the chain form ( 4 ) , whereas the reaction products obtained from ( 2 b ) and ( 2 c ) are y-hydroxy lactams (3). Accordingly, cleavage of the tert-butyl group from ( 4 ) , 151 (6 I / 7 A Z + E )
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