Evaluation of the dose-effect curves of dimethindene maleate enantiomers in various animal models

Leuschner, J; Neumann, Beate; Brunnauer, H.; Rehn, D

doi:10.1007/bf01997393

Cited by 2 publications

(2 citation statements)

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“…62 Dimetindene maleate toxicology studies have shown that it is safe for animals, with an LD 50 of 988 mg kg −1 for guinea pigs. 63 No increased teratogenic risk has been noticed 64 and there are recommended doses for children of 1 year and older. 65 Therefore, the new suggested compound is eco-friendly and considered safe for humans and animals, when used as an SAR inducer.…”

Section: Discussionmentioning

confidence: 99%

“…Although some studies have shown that tricyclazole is safe, other investigations have revealed that it has some harmful effects, such that toxin can impair testosterone secretion and the testicular structure, having an adverse effect on the sperm production system 62 . Dimetindene maleate toxicology studies have shown that it is safe for animals, with an LD 50 of 988 mg kg −1 for guinea pigs 63 . No increased teratogenic risk has been noticed 64 and there are recommended doses for children of 1 year and older 65 .…”

Section: Discussionmentioning

confidence: 99%

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The potential of dimetindene maleate inducing resistance to blast fungus Magnaporthe oryzae through activating the salicylic acid signaling pathway in rice plants

Salman

Ghoniem

Badr

et al. 2021

Pest Management Science

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BACKGROUND: Rice blast disease (Magnaporthe oryzae) is considered the most destructive rice disease all over the world. Dimetindene maleate is used in medication against allergic reactions in humans. Dimetindene maleate used to induce systemic acquired resistance (SAR) in rice (Oryza sativa L.) in order to protect rice plants from blast disease. RESULTS: Dimetindene maleate was not effective against fungus linear growth in vitro. In glasshouse conditions, dimetindene maleate significantly improved resistance at 25, 50, 125, 250, 500 and 1000 mg L −1 concentrations. Leaf blast severity reached 14.18% on plants treated with the most effective concentration of 125 mg L −1 compared with control plants. In field conditions during both seasons (2016 and 2017), 125 mg L −1 dimetindene maleate decreased the disease severity to 1.1% and 2.7%, respectively, after 30 days of treatment. Also, grain yield was increased to 13.27 and 12.90 t ha -1 in 2016 and 2017 seasons, respectively. Moreover, dimetindene maleate induces some of the indicators for salicylic acid and jasmonic acid pathways via gene expression. These genes include OsWRKY45, OsNPR1, AOS2, JAMYB and PBZ1 (OsPR10), recording 15. 14-, 16.47-, 5.3-, 5.37-and 5.1-fold changes, respectively, 12-h postinoculation.CONCLUSION: The results overview investigated the effectiveness of dimetindene maleate for increasing rice resistance to blast disease through inducing SAR in rice plants under glasshouse and field conditions, which could be through the SA defense pathway by expression of genes (OsWRKY45 and OsNPR1).

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Section: Discussionmentioning

confidence: 99%