This study focuses on peridomestic rat's identification within the University campus based on morphometry, providing unique landmarks for differentiation between Mastomys, Mus, Rattus and other rat species with emphasis on the need for more comprehensive investigation, categorization and morphometric profiling of rat population in Nigeria. Metric data generated for rat profiling in Nigeria is pivotal for a more comprehensive strategy for prevention of Lassa fever.
Serum copper, magnesium, zinc, calcium and ionized cal cium (Ca++) concentrations were compared in 6 rabbits infected with Trypanosoma brucei brucei and 5 uninfected rabbits. There was a significant depletion of Mg and Zn and a significant increase in Cu from about day 10 of infection to the end. There was no change in plasma total calcium or free diffusible calcium. There was a development of kidney damage as shown clinically by pro teinuria and urinary loss of magnesium and zinc, and histologi cally by the observation of hypercellularity in the glomeruli and tubular degeneration. Our findings thus indicate that trypanoso miasis causes kidney damage which may be responsible for the depletion of the cations seen in the study. Some of the clinical manifestations associated with African trypanosomiasis such as convulsions, anaemia, electrocardiographic changes and spleno megaly may therefore be related to these cation changes.Résumé : Cations dans les liquides somatiques de Trypanosoma brucei chez le lapin.Une comparaison de concentrations sériques du magnésium, du zinc et du calcium total et ionisé a été faite entre six lapins infectés par Trypanosoma brucei brucei et cinq lapins non infectés. On a pu montrer une baisse significative du magnésium et du zinc et une augmentation significative du cuivre à partir du dixième jour. Il n'y avait pas de modification du calcium total plamatique ni du calcium libre. Une atteinte rénale s'est traduite clinique ment, proétinurie associée à une perte urinaire du magnésium et du zinc, et histologiquement, hypercellularité des glomérules et dégénération tubulaire. Ces observations indiquent que la trypa nosomiase provoque des lésions rénales responsables de la baisse des cations sériques rapportée ici. Il est donc possible que des manifestations cliniques de la trypanosomiase humaine comme les convulsions, l'anémie, les perturbations électrocardiographiques et la splénomégalie puissent être rattachées, au moins partiellement, aux variations de ces cations.
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