Cations in body fluids of<i>Trypanosoma brucei</i>in infected rabbits

Amole, Babatunde O.; Thomas, K. D.; Asemota, D O

doi:10.1051/parasite/1990654155

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…However, little is known about the status of macronutrients and micronutrients excreted in the urine during parasitic infections, even though the kidneys are key detoxification organs and urine is a convenient material for rapid analysis. In rabbits infected with Trypanosoma brucei , increased excretion of magnesium (Mg) and zinc (Zn) in the urine has been observed [ 7 ]. Furthermore, children with schistosomiasis show significantly higher levels of iron (Fe) and copper (Cu) in urine, while manganese (Mn) and cadmium (Cd) concentrations are reduced in patients with acute Schistosoma haematobium infection with hematuria [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Macroelement and Microelement Levels in the Urine in Experimental Acanthamoebiasis

Łanocha-Arendarczyk,

Kot,

Baranowska-Bosiacka

et al. 2023

Pathogens

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Free-living amoebas can impact the excretion of macroelements and microelements in urine. The aim of the present study was to examine the concentrations of macroelements, including calcium (Ca), phosphorus (P), sodium (Na), potassium (K), and magnesium (Mg), as well as microelements such as manganese (Mn), zinc (Zn), copper (Cu), iron (Fe), and chromium (Cr), in the urine during acanthamoebiasis while considering the host’s immunological status. This is the first study to show an increase in urinary excretion of Ca, Mn, Cu, Fe, Na, and Cr, along with a decreased excretion of K, in immunocompetent mice 16 days post Acanthamoeba sp. infection. In the final phase of infection (24 dpi), there was a further decrease in urinary K excretion and a lower level of P in Acanthamoeba sp. infected immunocompetent hosts. During acanthamoebiasis in immunosuppressed hosts, increased excretion of Zn, Fe, and Cr was observed at the beginning of the infection, and increased Na excretion only at 16 days post Acanthamoeba sp. infection. Additionally, host immunosuppression affected the concentration of Fe, Cr, Zn, Cu, Mn, and Ca in urine.

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Section: Introductionmentioning

confidence: 99%

Macroelement and Microelement Levels in the Urine in Experimental Acanthamoebiasis

Łanocha-Arendarczyk,

Kot,

Baranowska-Bosiacka

et al. 2023

Pathogens

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Biochemical response of rabbits following experimental <i>trypanosoma brucei brucei</i> infection, treatment and re-infection

Oyewusi¹,

Saba²

2013

Sokoto J. Vet. Sc.

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The aim of this study was to determine the haematological changes induced by subchronic glyphosate exposure in Wistar rats and the ameliorative effect of zinc. Sixty adult male and female Wistar rats were used for the study. Twelve of them were used for the LD 50 which was evaluated to be 3750 mg kg -1 with clinical signs of respiratory distress, diarrhoea, rough hair coat and subsequently death observed. The remaining 48 rats were divided into six groups of four males and four females each. The agent(s) administered are as follows: Group I (DW), control, distilled water (2 ml kg -1 ), group II (Z), zinc (50 mg kg -1 ), group III (G), glyphosate (375 mg kg -1 , 10 % of the LD 50 ), group IV (Z + G), zinc (50 mg kg -1 ) and glyphosate (375 mg kg -1 ) while group V (GC), glyphosate (14.4 mg kg -1 ) and group VI (Z + GC), zinc (50 mg kg -1) and glyphosate (14.4 mg kg -1 ). The treatment regimens were administered orally by gavage once daily for eight weeks. At the end of the study, blood samples were collected and analysed but there were no statistical different (p>0.05) among the treatment groups. However, the haematological parameters were relatively higher in the groups treated with glyphosate alone except the lymphocyte which was relatively low in the glyphosate treated groups compared to the control group. These changes were suggestive of haematological toxicity induced by oxidative stress caused by glyphosate exposure. In conclusion, the alterations in the haematological parameters such as packed cell volume, hemoglobin concentration, total white blood cell count, neutrophils and lymphocyte counts induced by subchronic glyphosate exposure were found to be differentially ameliorated by pre-treatment with zinc.

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Response of Trypanosoma brucei bruceiinduced anaemia to a commercial herbal preparation

Erah¹,

Asonye²,

Okhamafe³

2003

Afr. J. Biotechnol.

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Jubi Formula® is a herbal preparation made from three medicinal herbs (Parquetina nigrescens, Sorghum bicolor and Harungana madagascariensis). It has been reported to have been successfully used in the treatment of anaemia in humans. A study was therefore carried out to determine the effect of the preparation on packed cell volume (PCV) and haemoglobin (Hb) concentrations in anaemic rabbits. The PCV and Hb concentrations of healthy rabbits infected with Trypanosoma brucei brucei were monitored for 49 days. T. b. brucei produced a significant reduction in PCV and Hb concentrations in all infected rabbits when compared with the controls (p<0.05). These hematological parameters were restored to normal levels in the anaemic rabbits by the herbal preparation. The anaemic rabbits not treated with the herbal preparation presented with a progressive decline in their PCV and Hb concentrations and majority of them died before the end of the study. Healthy rabbits that received daily doses of the herbal preparation showed gradual elevation in PCV and Hb concentrations which were maintained within normal range. Jubi Formula ® can restore the PCV and Hb concentrations in anaemic conditions and is a potential substitute for blood transfusion. However, further studies are needed to investigate the potentials of the herbal preparation in reversing anaemia.

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Cations in body fluids ofTrypanosoma bruceiin infected rabbits

Cited by 3 publications

References 17 publications

Macroelement and Microelement Levels in the Urine in Experimental Acanthamoebiasis

Macroelement and Microelement Levels in the Urine in Experimental Acanthamoebiasis

Biochemical response of rabbits following experimental <i>trypanosoma brucei brucei</i> infection, treatment and re-infection

Response of Trypanosoma brucei bruceiinduced anaemia to a commercial herbal preparation

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