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Calcium hydroxide - alkyl salicylate cements are based on bidentate chelate structures. All of the cements are hydrolytically unstable. The release of calcium, hydroxide, and salicylate ions into aqueous solution depends on the nature of the plasticizer.

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Acid-base reaction cements were produced by reacting copper oxide with phosphoric acid. When placed in the reticulo-rumen of cattle and sheep these cements released copper into the digestive tract for at least 3 months at a rate sufficient to provide the animals' requirements for copper. Lambs given a pellet of cement at 3 months of age had significantly greater concentrations of copper in their livers than similar untreated animals when slaughtered 3-4 months later. It was shown that salts of cobalt and selenium could be incorporated into the cement to provide additional supplementation with these two elements.